IndraLab

Statements

USP15 inhibits MDM2. 3 / 6
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"Such suicidal MDM2 auto-ubiquination can be blocked by USP15 deubiquitinase that prevents activation of NFATc2 mediated cytokine expression such as production of IFNgamma by Th1 effector T cells.Culli[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30099009
reach
"Conversely, whereas USP4 and USP15 target p53 inhibiting ligases ARF-BP1 [XREF_BIBR] and MDM2 [XREF_BIBR], respectively, USP11 stabilizes p53 [XREF_BIBR] as well as several other tumor suppressors including PML [XREF_BIBR], BRCA2 [XREF_BIBR] and Mre11 complex members MRE11 & RAD50 [XREF_BIBR]."
26503449
reach
"In resting T cells, MDM2 was stable even in the absence of USP15; however, the TCR+CD 28 signals stimulated ubiquitin dependent degradation of MDM2, which was negatively regulated by USP15."
24777531