IndraLab

Statements

Cyclin_E phosphorylates NPM1 on T199. 8 / 8
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"During the cell cycle, NPM is phosphorylated by cdk2-cyclin E on threonine 199 (T199) which causes the dissociation of NPM away from the centrosome and permits duplication."
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"30 NPM1 is phosphorylated on Thr199 by Cdk2 and cyclin E late in G 1 phase, 31 which causes dissociation of the majority of NPM1 from the centrosomes, a step required for centrosome duplication to occur."
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"In late G1, activated CDK2 and cyclin E phosphorylates NPM1 at T199, causing NPM1 to dissociate from centrosomes, an event essential for centrosome duplication."
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"As previously reported, phosphorylation of NPM1 by CDK2-cyclin E on threonine 199 triggers its dissociation from unduplicated centrosomes in the G1 phase, which promotes initiation of centrosome duplication [ xref ]."
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"One of the first steps required before the onset of centrosome duplication is the phosphorylation, by cyclin E dependent kinase activity, of nucleophosmin B at threonine 199 (T199)."
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"Early work by Fukasawa and collaborators showed that NPM1 is one of the most conspicuous targets of Cdk2 in unduplicated centrosomes and that phosphorylation of NPM1 on T199 by Cdk2-cyclin E leads to its dissociation from centrosomes ( xref , xref )."
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"In late G1, activated CDK2 and cyclin E phosphorylates NPM1 at T199, causing NPM1 to dissociate from centrosomes, an event essential for centrosome duplication 16."
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"Previous studies have shown that the human NPM’s phosphorylation by cyclin E–cyclin-dependent kinase 2 (cdk2) on threonine (Thr) 199 regulates its translocation from the centrosome during cell cycle progression."
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