IndraLab

Statements

Ubiquitin activates PSMD14. 3 / 3
| 3
reach
"Similar to CSN5, the Ins-1 loop of RPN11 undergoes conformational transition from inactive to active state, which is, in case of RPN11, directed by Ub and ATP [65]."
32708147
reach
"Importantly, all control experiments under single-turnover conditions revealed rate constants for the exponential depletion of Ub n substrate that matched the k cat values for multiple-turnover degrad[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28844860
reach
"We hypothesized that Rpn11 may act as the proteasome’s allosteric sensor and therefore introduced the A89F mutation, which increases Rpn11’s ubiquitin affinity by ~ 3-fold and turns it into a low-affinity receptor itself (Fig. 3A)."
39484543