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"PAD1 interacts with and citrullinates MEK1 to regulate extracellular signal– regulated kinase 1/2– matrix metallopeptidase 2 signaling, thus promoting tumorigenesis.25 Furthermore, accumulating evidences showing that overexpression of PAD2 and PAD4 were detected in a wide range of human malignant cancers,26 and that PAD inhibitors suppress the proliferation of cancer cell lines both in vitro and in vivo,25,27 supports the notion that PADs play important roles in tumorigenesis."