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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Modified ESR1 decreases the amount of IRS1. 1 / 1

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"Because ectopic expression of ERalpha reversed the I3C down-regulation of IGF1R and IRS1 transcript expression, the I3C disruption of ERalpha interactions with the IGF1R and IRS1 promoters mediates the I3C dependent loss of IGF1R and IRS1 gene expression, respectively."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...