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BRAF activates phosphorylated ERK. 7 / 7
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"Next, we analyzed the protein expression of MAPK and ERK signaling which regulates cell proliferation and differentiation, and we observed that FAM83F increased BRAF levels and induced the activation of pERK (XREF_FIG)."
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"Disruption of BRAF dimerization with the R509H mutation almost completely abolishes induction of p-MEK and p-ERK by class 3 BRAF mutants, but not by dimer independent BRAF (V600E) (XREF_FIG and XREF_FIG)."
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"BRAF siRNA reduced BRAF and p-ERK in transfected melanoma cells."
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"Intriguingly, RKO had only partial inhibition of pERK at 1microM (60% by densitometry); however dual PI3K and BRAF inhibition reduced pERK further (90% inhibition)."
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"Pharmacological inhibition of BRAF with vemurafenib and MEK with PD0325901 markedly reduced basal phospho-ERK (pERK) in melanoma cells while increasing SOX2, and this induction was specific to the inhibitor treatment as it was time dependent (XREF_FIG)."
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"In contrast, introduction of the P124S MEK1 mutant into human cells (HEK293) lacking oncogenic BRAF increased phospho-ERK signaling, suggesting that the oncogenic BRAF in melanoma cells was dominant over the 2 exon 3 MEK1 mutants with regard to ERK activation."
22588873
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"f Western blot analyses showing that B-Raf can activate p-ERK and that treatment with 20 muM HO-1 inhibitor ( ZnPPIX ) for 12 h can rescue the p-ERK expression of B-Raf ."
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