IndraLab

Statements

TGFBR1 phosphorylates SMAD3 on serine. 10 / 10
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"Upon TGF-beta1 stimulation, TbetaRI is activated by TbetaRII and mediates the phosphorylation of the conserved COOH-tail serine residues of Smad3."
26297431
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"Catalytically active TGF-beta type I receptor (TbetaRI) and activin type I receptor (ActRI) phosphorylate serine residues of receptor activated Smad2 and Smad3 [XREF_BIBR]."
22973518
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"Catalytically active TGF- β type I receptor (T β RI) and activin type I receptor (ActRI) phosphorylate serine residues of receptor-activated Smad2 and Smad3 [ xref ]."
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"The activated TbetaRI and TbetaRII complex phosphorylates the two C-terminal serine residues of receptor specific SMADs (R-SMADs), i.e., SMAD2 and SMAD3."
32583064
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"In the TGF-β-driven receptor complex, TGFBR2 phosphorylates and activates TGFBR1, which then phosphorylates SMAD2 and SMAD3 at two C-terminal serine residues."
30995507
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"Tgfbr1 phosphorylates Smad2 or Smad3 on two serine residues within their C-terminus enabling binding to Smad4 to form heteromeric Smad complexes that enter the nucleus and initiate gene transcription ( xref )."
30797519
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"The activated TbetaRI phosphorylates Smad3 at its COOH-terminal serine residue, which was enhanced with the 12-hour exposure of physiologically relevant concentration (5 mmol/L) of sodium butyrate in the culture medium for rat intestinal epithelial (RIE-1) cells."
19258539
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"The C-terminal serine residue of SMAD3 is phosphorylated by activated TGF-beta type I receptor (TbetaRI), whereas the linker domain is phosphorylated by other kinases, including MAPKs and cyclin dependent kinases."
26648552
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"Once activated, ACVR1B and TGFBR1 can phosphorylate Smad2 and Smad3 on C-terminal serine residues [ xref , xref ], and can also activate TGFB-activated kinase 1 (TAK1) [ xref , xref ]"
16384533
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"In the TGF-beta-driven receptor complex, TGFBR2 phosphorylates and activates TGFBR1, which then phosphorylates SMAD2 and SMAD3 at two C-terminal serine residues."
30995507