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BDNF inhibits KCNMA1. 7 / 7
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"More recent studies demonstrated that the reduced BK channel activity in DRG neurons after nerve injury is mediated by the increased BDNF through epigenetic and transcriptional mechanisms, and this BDNF-associated epigenetic regulation on pain is strongly related to the histone H3 and H4 acetylation at BDNF promoter I in the DRG that initiated at day 1 post-injury and lasted for 7 days [57]."
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"Our findings suggest that that nerve injury-induced increases in BDNF levels suppress BK channel activity in small and medium DRG neurons through TrkB receptors."
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"In this study, we showed that BDNF treatment reduced BK channel activity in small and medium DRG neurons from control rats."
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"In rats, nerve ligation (a model of peripheral nerve injury) increases brain-derived neurotrophic factor (BDNF), which causes a reduction in both mRNA and expression of the BK channel in the DRG, leading to an increase in excitatory transmission (Scholz and Woolf, 2007; Furukawa et al., 2008)."
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"BDNF can suppress N-type Ca channels (Bouron et al. 2006) and may reduce BK channel activity by decreasing Ca influx via these Ca channels."
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"Nerve Injury Increases Brain-Derived Neurotrophic Factor Levels to Suppress BK Channel Activity in Primary Sensory Neurons."
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"Moreover, because an increase in the intracellular Na concentration can suppress BK channel activity (Liang et al. 2008), BDNF may stimulate Na channels to increase the intracellular Na concentration via TrkB receptors (Kafitz et al. 1999)."
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