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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TP53BP1 methylates TP53. 2 / 2

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"For example, the 53BP1 tandem-Tudor domain binds to H4K20me3 and dimethylated p53 [XREF_BIBR, XREF_BIBR], and that of PHF20 has been shown to bind to lysine dimethylation of histones [XREF_BIBR] and p53 [XREF_BIBR]; in the latter case, PHF20 binding to p53 stabilizes p53 and promotes its activation during DNA damage response [XREF_BIBR]."

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"To further define the specificity, we examined interactions of the 53BP1 tandem Tudor domain with the other two methylated species of p53, known p53K370me2 XREF_BIBR, and yet to be identified p53K372me2, using NMR and fluorescence spectroscopy, and determined the 1.5 A and 1.9 A resolution crystal structures of the complexes (XREF_FIG)."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...