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KCNH2 activates Neoplasm Invasiveness. 18 / 18
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"In addition, block of hERG in immune-deficient mice decreased the bone marrow engraftment and peripheral blood invasion of myeloid/lymphoblastic leukemia cells and could overcome mesenchymal stroma ce[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pastori et al reported that lncRNA HOX transcript antisense RNA (HOTAIR) is an essential driver of GBM cell proliferation; overexpression of HOTAIR in conjunction with I‐BET151 treatment abrogates the antiproliferative activity of the BET bromodomain inhibitor.27 Shi et al found that lncRNA HERG promoted cell proliferation, migration, and invasion by acting as a ceRNA of miR‐940 in GBM.28 AC016405.3, also named RP11‐44N11.2, is a novel lncRNA located at chromosome 8, from 122 779 971 to 122 780 830."
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"HERG1 has also been shown to enhance GC cell invasion and proliferation, induce cell cycle progression in vitro, and promote tumor genesis and growth in vivo."
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"Silencing of hERG1 Gene Inhibits Proliferation and Invasion, and Induces Apoptosis in Human Osteosarcoma Cells by Targeting the NF-kappaB Pathway."
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"HERG1 silencing, as well as miR-96 over-expression inhibits the PDAC cell growth and invasiveness in vitro, and reduces tumorigenicity in vivo."
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"For instance, in human acute myeloid leukemia cells, hERG1 channels appear to mediate the vascular endothelial growth factor receptor-1-dependent cell migration and invasion, both in vitro and in vivo."
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"HERG potassium channels enhance tumor invasiveness and breast cancer proliferation."
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"The herg1 gene and HERG1 protein are expressed in many colon cancer cell lines, and the activity of HERG channels modulates colon cancer cell invasiveness."
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"HERG1 contributes to poor prognosis in patients with ESCC by promoting ESCC cell proliferation, migration, and invasion via TXNDC5 through the PI3K and AKT signaling pathway."
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"One study indicates that inhibition and silencing of the hERG1 protein prevent the proliferation and invasiveness of gastric cancer cells [66]."
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"HERG1 can increase oncogenic potential in leukemias by affecting one of several ways facilitating leukemogenesis : (1) balance between proliferation and cell death; (2) invasiveness, depending on the fine balance between adhesion and motility, the latter being in turn dependent on polarized volume changes; (3) resistance to chemotherapy [XREF_BIBR, XREF_BIBR]; (4) angiogenesis, via secretion of vascular endothelial growth factor (VEGF) and positively feedbacked microvesicles release [XREF_BIBR, XREF_BIBR]."
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"As presented in Fig. 4B-E, knockdown of hERG1 significantly reduced the migration and invasion abilities of SKOV3 cells."
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"Considering that inhibition of HERG channels reduces proliferation and impairs invasiveness in several cancer cell types, hERG channels expressed in HEK cells can be target receptor for compounds with[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This suggests that ER-G1 stimulates cancer cell proliferation by enabling tumor expansion rather than directly stimulating cell growth and division.Based on tumor morphology, we hypothesized that ER-G[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The results of the present study revealed that knockdown of hERG1 markedly reduced the migration and invasion abilities of ovarian cancer SKOV3 cells, which further suggests that hERG1 is an important regulator in the ovarian cancer phenotype."
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"Pharmacological inhibition of HERG channels reduces proliferation and impairs invasiveness in a variety of cancer cell types."
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"We conclude that in AML, hERG1 channels mediate the FLT-1-dependent cell migration and invasion, and hence confer a greater malignancy."
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"Esophageal squamous cell carcinoma (ESCC) is a highly aggressive and lethal malignancy worldwide that KCNH2 contributes to the poor prognosis of ESCC by promoting ESCC cell proliferation, migration, and invasion via TXNDC5 through PI3K and AKT phosphorylation [155]."
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