IndraLab

Statements

KCNH2 activates Neoplasm Invasiveness. 12 / 12
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"HERG1 can increase oncogenic potential in leukemias by affecting one of several ways facilitating leukemogenesis : (1) balance between proliferation and cell death; (2) invasiveness, depending on the fine balance between adhesion and motility, the latter being in turn dependent on polarized volume changes; (3) resistance to chemotherapy [XREF_BIBR, XREF_BIBR]; (4) angiogenesis, via secretion of vascular endothelial growth factor (VEGF) and positively feedbacked microvesicles release [XREF_BIBR, XREF_BIBR]."
25866806
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"This suggests that ER-G1 stimulates cancer cell proliferation by enabling tumor expansion rather than directly stimulating cell growth and division.Based on tumor morphology, we hypothesized that ER-G[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29136507
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"HERG potassium channels enhance tumor invasiveness and breast cancer proliferation."
31659098
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"HERG1 has also been shown to enhance GC cell invasion and proliferation, induce cell cycle progression in vitro, and promote tumor genesis and growth in vivo."
28264681
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"Invitro cell growth was unaffected, but ER-G1 strongly enabled matrix degradation and tissue invasion."
29136507
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"We conclude that in AML, hERG1 channels mediate the FLT-1-dependent cell migration and invasion, and hence confer a greater malignancy."
17420287
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"HERG1 silencing, as well as miR-96 over-expression inhibits the PDAC cell growth and invasiveness in vitro, and reduces tumorigenicity in vivo."
25719829
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"The herg1 gene and HERG1 protein are expressed in many colon cancer cell lines, and the activity of HERG channels modulates colon cancer cell invasiveness."
14744775
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"Pharmacological inhibition of HERG channels reduces proliferation and impairs invasiveness in a variety of cancer cell types."
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"HERG1 contributes to poor prognosis in patients with ESCC by promoting ESCC cell proliferation, migration, and invasion via TXNDC5 through the PI3K and AKT signaling pathway."
31331361
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"For instance, in human acute myeloid leukemia cells, hERG1 channels appear to mediate the vascular endothelial growth factor receptor-1-dependent cell migration and invasion, both in vitro and in vivo."
18663136
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"Silencing of hERG1 Gene Inhibits Proliferation and Invasion, and Induces Apoptosis in Human Osteosarcoma Cells by Targeting the NF-kappaB Pathway."
27076857