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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SIRT1 methylates TP53. 1 / 1

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"Both Sirt1 and Smyd2 can also deacetylate and methylate p53 on lysines, respectively, to impede p53 from binding to its target gene promoters, such as p21, and knockdown of Smyd2 enhances DNA damage-induced and p53-dependent apoptosis [ xref , xref ]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...