IndraLab

Statements

EGFR phosphorylates itself on Y1197. 11 / 11
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"This inhibitory effect of E-cadherin ligation on the mitogenic activity of EGFR was associated with a selective inhibition of EGFR phosphorylation at Tyr845 whereas no inhibition was observed for EGFR[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21665310
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"In addition, we observed here that HPV8E6 selectively enhances the EGFR autophosphorylation of Y1173 beyond that of Y1068."
30875834
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"The cells were treated with the growth factors for 2 minutes, the unbound factors were washed away, and the EGFR examined by immunoblotting cell extracts with an antibody that recognizes the receptor autophosphorylated on tyrosine 1173."
21640162
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"We showed the activation model of EGFR in the EGFR-nonaddictive H522 cells lacking c-Src activation, in which the autophosphorylation of EGFR at tyrosine 1173 was paralleled with the phosphorylated tyrosine 1068, 1086, and 1148 with the epidermal growth factor (EGF) addition ( xref ), while the phosphorylation of tyrosine 845, 1101, 974, and 992 was undetectable ( xref )."
34367939
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"Specifically, we showed that in old hepatocytes there is a decrease in autophosphorylation of EGF receptor at Tyr-1173."
23604425
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"EGFR was IPed from the cell lysates and IBed for total EGFR and receptor auto-phosphorylation on Y1173 and Y1068. xref shows that the L858R MT EGFR of H3255 cells is constitutively phosphorylated on Y1173 and Y1068, as expected ( xref ), which is further increased by both EGF and CS treatments, and that Erlotinib treatment could abolish the receptor auto-phosphorylation on Y1173 and Y1068 in control and EGF stimulation conditions."
23686837
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"Mechanistically, FBLN7 binds to the epidermal growth factor receptor (EGFR) through its EGF-like domain, together with the EGF-like calcium-binding domain, and induces EGFR autophosphorylation at tyrosine (Y) 1068 and Y1173, which activates downstream focal adhesion kinase/AKT signaling, thereby leading to fibroblast-to-myofibroblast transdifferentiation."
37344348
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"Western blot analyses indicated that treatment of trophoblastic SGHPL-5 cells and purified term trophoblasts with potentially EGF-contaminated hCG (hCG-A) resulted in auto-phosphorylation of the EGF receptor at tyrosine 1173 whereas supplementation of another urine-purified hCG preparation (hCG-B), recombinant holo-hCG or recombinant alphahCG had no effects."
16620962
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"In line with the result showing that EGF-elicited MAPK phosphorylation was not enhanced by LPC, EGF-induced autophosphorylation of EGFR at Tyr1173, which is involved in MAPK activation, was not affected by LPC ( xref D and E)."
23772401
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"PRMT5 monomethylates EGFR receptor at R1175 to increase trans- autophosphorylation of EGFR at Tyr (Y) 1173 [ xref ], which in turn provides a docking site for the SH2 domain of the phosphatase SHP1 (also known as PTPN6) ( xref )."
26305020
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"Consistent with the notion that cSrc is upstream of the EGFR, our findings also show that although the EGFR kinase inhibitor AG1478, inhibited EGFR autophosphorylation on Y1173 (not shown) and Erk1/2 as well as RSK activation ( xref ), the activation of c-Src by rapamycin was not altered ( xref ); these data also demonstrate that AG1478 did not inhibit c-Src activity."
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