IndraLab

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Endoplasmic reticulum activates KCNQ2. 4 / 4
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"Temperature elevation caused an unexpected increase in voltage dependent KCNQ2 channel activation but also increased the endoplasmic reticulum (ER) retention of KCNQ2 protein, and the ER retention was greater for mutants associated with BFNC than for wt KCNQ2."
28372301
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"We found that mutations in hA and hB underlying benign familiar neonatal convulsions (BFNC), an autosomal dominant form of neonatal epilepsy, weakened CaM binding, leading to reduced currents as a consequence of an endoplasmic reticulum (ER) retention of Kv7.2 subunits."
30022004
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"However, our results are consistent with the previous findings in HEK293T cells that CaM1234 modestly increases ER retention of wild-type KCNQ2 by 20% XREF_BIBR, XREF_BIBR."
25077630
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"Coexpression of Ca 2+ -insensitive CaM has been reported to moderately increase the ER retention of KCNQ2 by 20% in HEK293T cells XREF_BIBR, XREF_BIBR, suggesting that enrichment of KCNQ channels at the axonal surface may be regulated by Ca 2+ -bound CaM."
25077630