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AKT phosphorylates RAC1. 11 / 11
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"For instance, our studies showed that extranuclear signaling by E2 can activate the pro survival kinase, Akt which phosphorylates Rac1 and inhibits its activation."
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"Unlike its regulation of RhoA, the ubiquitination of Rac1 by SCF FBXL19 is accompanied by the phosphorylation of Rac1 by AKT."
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"Furthermore, we recently demonstrated that enhanced Akt activation leads to phosphorylation of Rac1 and deactivation of MLK3 in hippocampus CA1 following tyrosine phosphatase inhibition in animals that had undergone global cerebral ischemia."
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"Phosphorylation of Rac1 by Akt kinase was assayed with recombinant Rac1 protein and the fluorescein-labeled Rac1 peptide."
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"Phosphorylation of Rac1 by Akt kinase was assayed with recombinant Rac1 protein and the fluorescein labeled Rac1 peptide."
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"Akt can phosphorylate in vitro the Rho GTPase Rac1, inhibiting its GTP binding activity 41; the relevance of this observation to cell motility is not yet established."
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"Rac1 is phosphorylated on 71 S by Akt, which does not change Rac1 GTPase activity of Rac1, but inhibits its binding to GTP [ xref ]."
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"We confirmed that inhibition of PI3K and Akt significantly decreased Rac1 phosphorylation in cultured human keratinocytes (XREF_FIG)."
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"Ser71 (64yrplsyp73) is a conserved Akt site on RAC1 that can be phosphorylated by Akt."
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"For instance, our studies showed that extranuclear signaling by E2 can activate the pro-survival kinase, Akt which phosphorylates Rac1 and inhibits its activation."
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"It was shown that the Rac1 peptide and the recombinant protein were phosphorylated by the activated recombinant Akt kinase and the lysate of SK-MEL28 cells, a human melanoma cell line."
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