IndraLab

Statements

Toxin inhibits KCNB1. 2 / 2
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sparser
"The sequence of GxTX-1E is similar to toxins known to interact with voltage sensors ( xref ) and electrophysiological studies show that the toxin inhibits Kv2.1 by modifying gating ( xref , xref ) and that mutations in the S3b-S4 paddle region of the voltage-sensing domain of Kv2.1 weaken toxin affinity ( xref )."
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sparser
"This toxin does not inhibit Kv2.1 (in Xenopus oocytes), and yet it does inhibit the paddle chimera, which contains the Kv2.1 voltage sensor paddle xref ."
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