IndraLab

Statements

BAP1 activates cell differentiation. 15 / 15
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"Interestingly, ASXL1-MT and BAP1 promotes monocyte differentiation, while it inhibits terminal differentiation to macrophage, which may account for the frequent (40-50%) detection of ASXL1 mutations in CMML patients."
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"6 In line with these findings, several reports have indicated that truncated ASXL1 enhances BAP1 complex activity, thereby promoting depletion of the H2AK119Ub mark and aberrant myeloid differentiation."
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"BAP1 reduction significantly decreased the colony-forming capacity of ASXL1 mutant primary AML cells, and partially rescued the differentiation block in myeloid cells."
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"Paradoxically, recent findings have confirmed that BAP1 also promotes growth and differentiation even in uveal melanomas where loss of BAP1 expression is a common event."
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"As a deubiquitinating enzyme, BAP1 contributes to gene transcription, cell differentiation, DNA damage repair, apoptosis, and cell metabolism in tumor inhibition."
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"Moreover, BAP1’s modulation of cell differentiation through HDACs and EZH2 expression levels holds promise for understanding and potentially addressing pregnancy complications characterized by aberrant epigenetic modifications."
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"BAP1 depletion caused a reduction in mRNA levels of neural crest migration genes (ROBO1), melanocyte differentiation genes (CTNNB1, EDNRB and SOX10) and other genes that are down-regulated in class 2 tumors (LMCD1 and LTA4H)."
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"Both ASXL1 and BAP1 were downregulated during RA induced P19 cell differentiation with concomitant increase of ubiquitinated H2B, leading to activation of Hox genes."
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"In the monocyte and macrophage differentiation assay, coexpression of ASXL1-MT and BAP1 substantially promoted differentiation toward CD115 + monocytes while inhibiting their terminal differentiation to CD115 + F4/80 + macrophages."
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"Downregulation of ASXL1 and BAP1 Promotes Hox Gene Exp (A) Downregulation of ASXL1 and BAP1 during RA induced differentiation."
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"Then, these effects were observed in primary leukaemia samples with ASXL1 mutation that BAP1 reduction significantly decreased the colony-forming capacity and promoted the differentiation of blast cel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Concomitant Bap1 and Ezh2 loss reduced myeloid progenitor expansion, reduced the proportion of Mac1 + Gr1 + myeloid cells, restored erythroid differentiation (CD71 + Ter119 +) and decreased proliferation of Bap1 and Ezh2 deficient progenitors (XREF_FIG and XREF_SUPPLEMENTARY)."
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"Flow cytometric and morphological analyses indicated that BAP1 reduction partially rescued the differentiation block of AML cells and promoted blast cells differentiation into mature myeloid and eryth[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Both ASXL1 and BAP1 were downregulated during RA induced P19 cell differentiation with concomitant increase of ubiquitinated H2B, leading to activation of Hox genes."
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"BAP1 promotes progenitor cell differentiation into melanocytes by increasing MITF expression and BAP1 loss may promote metastasis in UM by remodeling the epigenome to resemble that of stem-like migratory neural crest cells."
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