IndraLab

Statements

BAP1 inhibits RCC. 3 / 3
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"Taken together these data show that BAP1 binding to HCF-1 is likely to be important for BAP1 suppression of RCC development."
22683710
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"XREF_BIBR Immunohistochemistry for BAP1 was performed on tissue microarray sections from 559 non metastatic RCC cases treated with nephrectomy : BAP1 was negative in 82 of 559 tumors (14.7%), and Cox regression indicated a significantly worse disease-free and overall survival for patients negative for BAP1 protein compared to patients with BAP1 positive tumors."
24855403
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"Thus, BAP1 mutation in the germline may predispose to RCC, in which case, RCC development may also be initiated by loss of BAP1."
22683710