IndraLab

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USP14 inhibits apoptotic process. 23 / 26
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"We found that USP14 inhibition significantly induced apoptosis, as evident by PARP cleavage, and downregulation of the anti-apoptotic protein Bcl-2, in AR + / ER - breast cancer, and moderately induced apoptosis in AR + / ER + MCF7 cells."
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"USP14 was discovered to negatively regulate cell apoptosis by interacting with Bcl-xl and upregulating its level."
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"Thus, knockdown of USP14 sensitized GC cells to cisplatin by triggering cisplatin-induced apoptosis via impeding Akt and ERK signaling pathways."
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"Inhibition of USP14 causes G 0 / G 1 arrest and apoptosis in breast cancer cells."
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"Flow cytometry revealed that the reduced expression of USP14 induced the apoptosis of the SKOV3 EOC cells."
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"b-AP15, a small molecule inhibitor of two 19S regulatory-particle-associated deubiquitinases, USP14 and ubiquitin C-terminal hydrolase 5, could efficiently induce cell apoptosis or cell death in colorectal cancer cell line HCT116.24 In addition, b-AP15 can suppress the growth of FaDu squamous cell carcinoma cells.25 Our stratified survival analysis indicated that high USP14 expression could distinguish poor outcomes of patients with either early (TNM stage I-II) or advanced clinical stage (TNM stage III-IV), suggesting that USP14 may play a significant role throughout the development of ESCC."
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"Pharmacologic inhibition of USP14 and UCHL5 with VLX1570 induces apoptosis in drug resistant WM cells and is associated with accumulation of high-molecular-weight polyubiquitinated protein conjugates."
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"Overexpression of USP14 could enhance proliferation, prevent apoptosis and promote invasion and migration of PDAC cells."
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"19 In addition , small USP14 inhibitors , such as WP1130 , b-AP15 , AC17 , and pyrithione , could dramatically suppressed cell proliferation and promoted apoptosis in various malignancies.9 , 20 , 21 , 22 , 23 , 24 However , we did not observe any disturbed biological process , such as cell cycle progression , cell proliferation , and apoptosis , in USP14-deficient GC cells , although silencing of USP14 dramatically inhibited Akt and ERK signaling pathways ."
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"The USP14 has been used to inhibit proteasomal function inducing apoptotic cell death in cancers [39]."
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"Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenstrom macroglobulinaemia tumour cells."
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"Additionally, AR overexpression inhibited cell apoptosis and growth suppression induced by USP14 silencing or IU1 treatment."
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"Along with others, we previously have been reported that inhibition of USP14 and UCHL5 of the 19S proteasome induces apoptosis."
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"Both genetic knockdown and pharmacological inhibition of USP14 inhibits the proliferation and induces the apoptosis of AR-positive breast cancer cells (Table 2)."
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"Inhibition of USP14 and UCHL5 activates caspase and triggers apoptosis of ER + BCa cells."
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"On the contrary, administration of b-AP15, a specific inhibitor of USP14, significantly increased leukemia cells apoptosis in a dose dependent manner."
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"Recently, novel small molecule inhibitors of the deubiquitylating enzymes USP14 and UCHL5 were developed to overcome bortezomib resistance and induce cell apoptosis of multiple myeloma XREF_BIBR, XREF_BIBR."
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"USP14 inhibition via administration of IU1 or USP14 specific siRNA and shRNA enhanced cell growth inhibition and apoptosis induction by enzalutamide in breast cancer cell lines in vitro and in vivo."
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"USP14 depletion induced apoptosis in cisplatin-treated GC cells ."
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"As shown in XREF_FIG, USP14 inhibition or silence failed to induce apoptosis or PARP cleavage but instead induced moderate decreases of p53 and Bax, suggesting that cell growth suppression mediated by USP14 inhibition or silence is through promoting cell proliferation, independent of cell death."
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"These findings support our hypothesis that pharmacological inhibition of USP14 triggers apoptosis in endometrial cancer cells."
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"Functionally, overexpression of USP14 inhibits chemotherapeutic drugs induced apoptosis in leukemia cells."
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"We also found that USP14 inhibitors did not induce apoptosis but actually induced autophagy through accumulation of ubiquitinated proteins / ER stress / unfolded protein response ( UPR ) axis ."
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