IndraLab

Statements

USP14 inhibits apoptotic process. 54 / 57
| 3 51
reach
"USP14 can also promote cell growth and inhibit cell apoptosis in AR-positive ERα-negative BCa (16)."
36423684
reach
"Collectively, these data revealed that the overexpression of USP14 promoted HNSCC proliferation and metastasis and decreased cell apoptosis in vitro."
37686660
reach
"SmUCHL5 was expressed at low levels at 10 µM, and research on mammalian cells has shown that the inhibition of UCHL5 and USP14 activates autophagy and apoptosis ( Feng et al., 2014 ; Kim et al., 2018 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33577811
reach
"Functionally, USP14 overexpression reduced apoptosis and increased cell migration, invasion, and EMT in vivo and ex vivo."
37917013
reach
"We found that USP14 inhibition significantly induced apoptosis, as evident by PARP cleavage, and downregulation of the anti-apoptotic protein Bcl-2, in AR + / ER - breast cancer, and moderately induced apoptosis in AR + / ER + MCF7 cells."
29353883
reach
"In summary, these results substantiated that USP14 initiated the NF-κB signaling pathway to induce EMT and suppress apoptosis (Figure 8)."
37917013
eidos
"We also found that USP14 inhibitors did not induce apoptosis but actually induced autophagy through accumulation of ubiquitinated proteins / ER stress / unfolded protein response ( UPR ) axis ."
32632734
reach
"We previously reported that USP14 was significantly overexpressed in OSCC and that knockdown of USP14 markedly inhibited tumor growth and triggered apoptosis in cancer cells [16]."
38388430
reach
"More importantly, knockdown of USP14 suppressed cell proliferation, altered the cell cycle, and induced cell apoptosis."
31676235
reach
"We found that sh-USP14 significantly inhibits the proliferation, invasion, and invasion of liver cancer cells, promoting apoptosis."
38383348
reach
"More recently, Hang et al. reported that USP14 promoted cell proliferation, invasion, and migration and prevented apoptosis in vitro [34]."
35906484
reach
"These data suggested that USP14 suppression could promote the role of IR in inducing apoptosis to suppress OSCC progression.Considering the negative correlation between USP14 and LC3B, we then explore[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33212146
reach
"Overexpressing USP14 reduced apoptosis and promoted EC cell migration and invasion."
37917013
reach
"b-AP15, a small molecule inhibitor of two 19S regulatory-particle-associated deubiquitinases, USP14 and ubiquitin C-terminal hydrolase 5, could efficiently induce cell apoptosis or cell death in colorectal cancer cell line HCT116.24 In addition, b-AP15 can suppress the growth of FaDu squamous cell carcinoma cells.25 Our stratified survival analysis indicated that high USP14 expression could distinguish poor outcomes of patients with either early (TNM stage I-II) or advanced clinical stage (TNM stage III-IV), suggesting that USP14 may play a significant role throughout the development of ESCC."
28509417
reach
"Both genetic knockdown and pharmacological inhibition of USP14 inhibits the proliferation and induces the apoptosis of AR-positive breast cancer cells (Table 2)."
35069211
reach
"The results revealed that upregulating USP14 facilitated the colony-forming ability of HEC-1-B and SNG-M and reduced apoptosis (vs. the vector group, Figure 2B, 2C)."
37917013
reach
"USP14 also plays important roles in tumor death, for example, USP14 inhibits hepatocellular carcinoma apoptosis by stabilizing the GPX4 protein [49], and the inhibition of USP14 increases the degree of gastric cancer apoptosis, with an increased expression of cleaved caspase-3 and cleaved PARP [50]."
37686660
reach
"Recently, novel small molecule inhibitors of the deubiquitylating enzymes USP14 and UCHL5 were developed to overcome bortezomib resistance and induce cell apoptosis of multiple myeloma XREF_BIBR, XREF_BIBR."
33046988
reach
"USP14 was discovered to negatively regulate cell apoptosis by interacting with Bcl-xl and upregulating its level."
29479529
reach
"The USP14 has been used to inhibit proteasomal function inducing apoptotic cell death in cancers [39]."
35793039
reach
"Also, over-expressing USP14 markedly decreased the apoptosis rate in OSCC cells after IR treatment."
33212146
reach
"40 , 41 USP14 inhibits apoptosis by inhibiting the bcl‐XL signaling pathway and promotes proliferation by stimulating the Wnt signaling pathway in multiple myeloma."
37035133
reach
"Along with others, we previously have been reported that inhibition of USP14 and UCHL5 of the 19S proteasome induces apoptosis."
28617443
reach
"Inhibition of USP14 and UCHL5 activates caspase and triggers apoptosis of ER + BCa cells."
30250021
reach
"Flow cytometry revealed that the reduced expression of USP14 induced the apoptosis of the SKOV3 EOC cells."
25429837
reach
"Furthermore, USP14 depletion similarly sensitized HNSCC cells to TNF-induced apoptosis (Fig. 6D; representative images in Supplementary Fig. 11D)."
37055579
reach
"A previous study has highlighted that USP14 contributed to cell growth, migration, the activation of kinase and inflammasome, as well as inhibited autophagy and apoptosis in cancer cells 14."
37082728
reach
"USP14 had elevated expression in epithelial ovarian cancer tissues, and the knockdown of USP14 could induce cell apoptosis through the Bcl-xl pathway to inhibit cell proliferation 12, 15."
37082728
reach
"These findings support our hypothesis that pharmacological inhibition of USP14 triggers apoptosis in endometrial cancer cells."
27121063
reach
"Furthermore, the flow cytometric analysis revealed that the overexpression of USP14 in TU177 cells reduced cell apoptosis compared to the control or Flag-USP14 C114A (Figure 4H)."
37686660
reach
"The inhibition of USP14 activity triggers antiproliferative effects and apoptosis, which result in cell death (15, 19, 20)."
37401238
reach
"In addition, the genetic inhibition of USP14 suppresses cell proliferation and enhances cell apoptosis in human hepatocarcinoma SMMC7721 cells ( Huang et al., 2015 )."
29454609
reach
"Pharmacologic inhibition of USP14 and UCHL5 with VLX1570 induces apoptosis in drug resistant WM cells and is associated with accumulation of high-molecular-weight polyubiquitinated protein conjugates."
27813535
reach
"USP14 inhibition protects murine osteoblastic cells against DEX-induced apoptosis ."
39814826
reach
"Overexpression of USP14 could enhance proliferation, prevent apoptosis and promote invasion and migration of PDAC cells."
33394290
reach
"Inhibition of USP14 activity induced apoptosis in gastric cancer cells ."
37401238
reach
"In this study, USP14 promoted the G1-S phase transition of Hela and Siha cells and inhibited cell apoptosis, thereby promoting the proliferation, migration, and invasion of CC cells."
38069565
reach
"In gastric cancer, inhibition of USP14 activity has been found to induce apoptosis through the inactivation of the Akt and ERK signaling pathways (18, 22, 30)."
37401238
reach
"As shown in XREF_FIG, USP14 inhibition or silence failed to induce apoptosis or PARP cleavage but instead induced moderate decreases of p53 and Bax, suggesting that cell growth suppression mediated by USP14 inhibition or silence is through promoting cell proliferation, independent of cell death."
28151478
reach
"Inhibition of USP14 causes G 0 / G 1 arrest and apoptosis in breast cancer cells."
29353883
reach
"Functionally, overexpression of USP14 inhibits chemotherapeutic drugs induced apoptosis in leukemia cells."
28662510
reach
"On the contrary, administration of b-AP15, a specific inhibitor of USP14, significantly increased leukemia cells apoptosis in a dose dependent manner."
28662510
reach
"Moreover, the USP14 overexpression could enhance the proliferation, migration, and invasion and also reduce apoptosis of PDAC cells via regulating the expression of cyclin D1, PCNA, and E-cadherin [25]."
36582601
reach
"For example, researchers have discovered inhibitors, like b-AP15 to covalent inhibition of both USP14 and UCHL5 to induce the cathepsin-dependent apoptosis by inhibiting the UPS system [131]."
37658402
reach
"5D and S4D , overexpression of USP14 significantly enhanced the spheroid formation and growth rate of SPC-A1 and NCI-H1650 cells transfected with the USP14 overexpression plasmid compared with negativ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29702194
reach
"In fact, it has been reported that b-AP15, an inhibitor of USP14, increased ER stress and apoptosis owing to abnormal accumulation of polyubiquitinated proteins in cancer cells [8] ."
26768359
reach
"These findings suggest that USP7 inhibitors may represent a novel approach for treating high-risk NB with MYCN amplification and non-p53 mutations, both as a monotherapy and as an effective adjunct to existing chemotherapy regimens.b-AP15, a small-molecule inhibitor targeting USP14, has been shown to induce apoptosis and inhibit cell proliferation in NB."
39391247
reach
"Flow cytometry analysis was used to examine the cell cycle and apoptosis, and the results showed that knockdown of USP14 significantly inhibited the G1/S phase transition in PDAC cells (Fig. S5E, F), and increased apoptosis (Fig. S5G, H)."
35906484
reach
"Thus, knockdown of USP14 sensitized GC cells to cisplatin by triggering cisplatin-induced apoptosis via impeding Akt and ERK signaling pathways."
30296012
eidos
"USP14 depletion induced apoptosis in cisplatin-treated GC cells ."
30296012
reach
"In contrast, USP14 promoted tumor progression and suppressed apoptosis in HCC via the downregulation of caspase-3 and upregulation of BCL-2 protein [56]."
35884607
reach
"Additionally, AR overexpression inhibited cell apoptosis and growth suppression induced by USP14 silencing or IU1 treatment."
29353883
eidos
"19 In addition , small USP14 inhibitors , such as WP1130 , b-AP15 , AC17 , and pyrithione , could dramatically suppressed cell proliferation and promoted apoptosis in various malignancies.9 , 20 , 21 , 22 , 23 , 24 However , we did not observe any disturbed biological process , such as cell cycle progression , cell proliferation , and apoptosis , in USP14-deficient GC cells , although silencing of USP14 dramatically inhibited Akt and ERK signaling pathways ."
30296012
reach
"Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenstrom macroglobulinaemia tumour cells."
25691154