IndraLab

Statements

REST inhibits HCN1. 4 / 4
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"NRSF can also repress the genes HCN1 and KCC2, which can regulate neural activity through ion channels."
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"Indeed, a common regulatory mechanism consisting of an increase in the expression of the repressor NRSF and REST (Neuron Restrictive Silencer Factor), that potently represses HCN1 and other key neuronal genes, might exist in these scenarios."
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"This phenomenon might be partly due to REST mediated transcriptional repression of Hcn1 56."
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"NRSF dependent downregulation of HCN1 in vitro."
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