IndraLab

Statements

KCNMA1 activates Neoplasm Invasiveness. 17 / 19
| 17
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"KCNMA1 amplification favors human prostate cancer proliferation whereas siRNA block of KCNMA1 significantly reduces breast cancer invasion."
22584144
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"Penitrem A, a selective BK channel blocker, was demonstrated to reduce breast cancer cell proliferation and invasion through the Wnt/beta-catenin pathway [114,120,121]."
38474212
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"Furthermore, KCa1.1 blockers and siRNA inhibited the invasiveness of PIA-FLS, suggesting that KCa1.1 plays a major role in the regulation of PIA-FLS function, regardless of the possible expression of other potassium channels."
25252152
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"This could account for how the SLO activation of EGFR reported here produces significant inhibition of MDA-MB-231 cell invasion, whereas in previous reports EGF added to MDA-MB-231 cells had no effect, or produced some increase in invasion [XREF_BIBR - XREF_BIBR]."
21787862
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"K ATP channel blockers including glybenclamide are widely used for the treatment of type II diabetes mellitus.In the present study, we found that both paxilline, a BK channel blocker, and glybenclamid[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22673517
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"In vitro studies proved that knockdown of KCNMA1 inhibited cell proliferation or invasiveness in different types of cancer, such as glioblastoma, breast and prostate cancer, although this not seemed to apply to all [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25397596
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"On the other hand, in the metastatic breast cancer cell lines MCF7, MDA-MB-231, and MDA-MB-361, KCNMA1 promotes cell invasiveness and transendothelial migration, which could be attenuated by siRNA knockdown or inhibition with Iberiotoxin [XREF_BIBR]."
30791468
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"Studies on brain specific breast metastasis reveal that increased expression of KCNMA1, a gene encoding for a big conductance type potassium channel (BKCa) that is upregulated in breast cancer, leads to greater invasiveness and transendothelial migration [XREF_BIBR]."
22481931
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"Furthermore, BK channel is also reported to promote breast cancer and glioma invasion and migration; however, there is limited evidence of the role of BK channel in OS invasion and metastasis."
30720085
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"The coordinated actions of NADase and SLO in increasing cytotoxicity , enhancing invasiveness , promoting intracellular survival , and mediating immune evasion have been well-documented, illustrating the uniqueness and specificity of GAS pathogenesis."
36721030
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"Further research is required to understand exactly how the loss of KCNMA1 activity and resultant changes in Ca 2+ flux reduces migration and invasion without impacting apoptosis, and is beyond the scope of the current study."
27245839
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"Hu et al. demonstrated that blocking of the KCa1.1 channel with tetraethylammonium (TEA) disturbs the calcium homeostasis and inhibits the proliferation, invasion, and production of VEGF, IL-8, and pro-MMP 2 by RA FLs."
38783950
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"Addition of SLO increased host cell invasion by T. cruzi trypomastigotes in a dose dependent manner (XREF_FIG)."
21536739
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"The expression of KCNMA1 , contributes to high cellular proliferation and increased invasiveness of melanoma cell lines [112] ."
24513178
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"Additionally, inhibition of the BK channel was shown to attenuate the invasiveness and migratory abilities of the breast cancer cells, highlighting the role of this K + channel in the metastatic prope[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29748137
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"Unsurprisingly, blockade of the BK channel with paxilline disrupts Ca homeostasis and prevents RA-FLS proliferation and invasion by inhibiting cytokine and MMP production."
37047767
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"The KCa1.1 channel agonist phloretin increased PIA-FLS invasiveness in the absence of siRNA and in the presence of control siRNA."
25252152