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Phosphorylated AKT phosphorylates GSK3. 10 / 10
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"Notably H-89, at the concentration that was used (10 µM), did not inhibit the activity of Akt, S6K1, and RSK as measured by p-Akt, p-S6K1, and p-RSK, which can phosphorylate GSK3, while inhibiting PKA as measured by p-CREB and p-VASP1 xref , xref (Supplementary Fig.  xref )."
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"Treatment with 10 µM MK-2206, an Akt inhibitor widely used in the clinical trials for cancer indicated a significant decrease in the expression of phosphorylated Akt, Phosphorylated GSK-3α/β, claudin-5, ZO-1 and ZO-2 protein levels compared to DMSO-treated controls in HLECs (Fig. 5a–d)."
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"Conversely, other groups reported the opposite: they observed increases in p-Akt and p(Ser)-GSK3 in AD brain samples (Pei et al., xref ; Griffin et al., xref ; Yarchoan et al., xref )."
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"P-AKT could phosphorylate the GLUT4 and GSK3β to promote glucose metabolism and regulates cell cycle [29–33]."
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"Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation [..."
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"It is well known that inhibition of AKT phosphorylation downregulates GSK3β phosphorylation, thereby inhibiting glycogen synthase (GS) activity [46]."
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"Riluzole Decrease AKT Phosphorylation and AKT mediated GSK3 Phosphorylation."
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"This inhibition of p-Akt prevents the phosphorylation of GSK3β and cell proliferation (Roudier et al., 2006)."
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"Increased phosphorylation of Akt (increased Akt activities) causes phosphorylation of GSK3β (suppression of GSK3β activities) at the serine 9 residue while reduced phosphorylation of Akt (reduced Akt activities) decreases levels of phosphorylation of GSK3β (increased GSK3β activities)."
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"Our results showed that Akt phosphorylation was increased, which paralleled the enhancement of GSK-3 phosphorylation, in either the BHD- or TPA treated mouse brain (XREF_FIG)."
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