IndraLab

Statements

EGF leads to the phosphorylation of STAT1 on S727. 7 / 7
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"It was observed that inhibition of ERK½ by U0126 in HTR-8/SVneo cells resulted in concomitant inhibition of EGF-induced increase in STAT1 and STAT3 phosphorylation at ser 727 along with inhibition of degradation of total STAT1 (Figs xref and xref )."
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"Both EGF and IFN-γ are able to cause phosphorylation of Stat1 at both Tyr701 and Ser727 for its full activation."
22162832
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"Indeed, we found that both EGF and IFN-gamma strongly activated Stat1 phosphorylation at both Ser727 and Tyr701 in U87-EGFR cells."
22162832
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"Indeed, we found that both EGF and IFN-γ strongly activated Stat1 phosphorylation at both Ser727 and Tyr701 in U87-EGFR cells."
22162832
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"The effects of different cytokines on STAT1 S727 phosphorylation in WT and dKO 293 cells are shown in xref D. While the tested cytokines had little effect in the WT cells, the lower basal STAT1 S727 phosphorylation in the dKO cells (lacking CDK8/19) was increased by EGF, TNFα and serum. xref E shows that CDK8/19-independent STAT1 S727 phosphorylation in dKO 293 cells was also increased by cytotoxic drugs etoposide and Taxol; the time course of the induction of CDK8/19-independent STAT1 S727 phosphorylation by 50 nM Taxol in dKO 293 cells is shown in xref F."
31717492
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"While the tested cytokines had little effect in the WT cells, the lower basal STAT1 S727 phosphorylation in the dKO cells (lacking CDK8/19) was increased by EGF, TNFα and serum."
31717492
reach
"Both EGF and IFN-gamma are able to cause phosphorylation of Stat1 at both Tyr701 and Ser727 for its full activation."
22162832