A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.



phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

BRAF binds ARAF and RAF1. 4 / 4
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"GDC-0879 was designed to target a specific BRAF mutation (BRAF V600E ) often found in melanomas, but it also binds wild type BRAF, CRAF and ARAF, with minimal efficacy against other kinases ( xref ; xref )."
"Ras-GTP promotes the formation of active homodimers or heterodimers of A-Raf, B-Raf, and C-Raf by an intricate process."
"Through interaction with A-Raf, B-Raf and Raf-1, Ras activates the mitogen activated protein (MAP) kinase kinases MEK 1 and 2, and in turn the MAP kinases ERK 1 and 2."
"As summarized in Figure 1 E, LY3009120 bound to ARAF, BRAF, and CRAF proteins with similar affinities of 44, 31–47, and 42 nM, respectively."