"GDC-0879 was designed to target a specific BRAF mutation (BRAF V600E ) often found in melanomas, but it also binds wild type BRAF, CRAF and ARAF, with minimal efficacy against other kinases ( xref ; xref )."
"Ras-GTP promotes the formation of active homodimers or heterodimers of A-Raf, B-Raf, and C-Raf by an intricate process."
"Through interaction with A-Raf,
B-Raf and Raf-1, Ras activates the mitogen activated protein (MAP)
kinase kinases MEK 1 and 2, and in turn the MAP kinases ERK 1 and 2."
"As summarized in Figure 1 E, LY3009120 bound to ARAF, BRAF, and CRAF proteins with similar affinities of 44, 31–47, and 42 nM, respectively."