IndraLab

Statements

BRAF binds ARAF and RAF1. 6 / 6
| 6
sparser
"Ras-GTP promotes the formation of active homodimers or heterodimers of A-Raf, B-Raf, and C-Raf by an intricate process."
30118796
sparser
"To activate downstream members of the MAPK pathway, Ras-GTP stimulates the formation of an active homodimer or heterodimer consisting of A-Raf, B-Raf, and C-Raf through a complex process [ xref ]."
33836754
sparser
"PKCα forms complexes with A-Raf, B-Raf and C-Raf that dissociate upon pathway activation, and all three Raf isoforms can mediate PKCα-induced anti-proliferative effects."
35697074
sparser
"As summarized in Figure 1 E, LY3009120 bound to ARAF, BRAF, and CRAF proteins with similar affinities of 44, 31–47, and 42 nM, respectively."
26343583
sparser
"GDC-0879 was designed to target a specific BRAF mutation (BRAF V600E ) often found in melanomas, but it also binds wild type BRAF, CRAF and ARAF, with minimal efficacy against other kinases ( xref ; xref )."
29249695
sparser
"Through interaction with A-Raf, B-Raf and Raf-1, Ras activates the mitogen activated protein (MAP) kinase kinases MEK 1 and 2, and in turn the MAP kinases ERK 1 and 2."
9529605