
IndraLab
Statements
reach
"As demonstrated in XREF_FIG, Lv-shRNA-TREK-1 infection significantly decreased TREK-1 mRNA and protein expression (P < 0.05) in astrocytes compared with Lv-shRNA-sham cells, and inhibited the effect of 1.0 and 1.5 MAC isoflurane on the expression of TREK-1, BDNF, Bax and caspase-3 (P < 0.05)."
reach
"For example, although knockout of the TREK1 potassium channel increases the MAC of chloroform, desflurane, halothane, and sevoflurane, XREF_BIBR the increase is usually small and, more importantly, it is inconsistent, varying from 7% (desflurane) to 48% (halothane), and these changes do not correlate with the in vitro effects of these anesthetics on the TREK1 potassium channel."