IndraLab

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USP7 decreases the amount of MDM2. 6 / 10
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"3b indicates that PDGF dramatically increased MDM2 protein level to 2.63-fold over control, while pre-silencing of USP7 reduced MDM2 protein level to 0.99-fold over control (P < 0.05 versus PDGF-treated cells)."
34552711
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"UbV.7.2 inhibited USP7 in cancer cells, and consequently, caused dramatic reductions of MDM2 levels and induction of apoptosis, in synergy with cisplatin, suggesting that UbVs could be used as enhancers of chemotherapeutic drugs."
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"Indeed, downregulation of USP10 did not affect Mdm2 levels in p53 deficient cells (XREF_FIG and XREF_SUPPLEMENTARY), while downregulation of HAUSP still decreased Mdm2 levels in p53 deficient cells."
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"Eventually, the hepatocellular carcinoma is induced, or the inhibited USP7 protein elevates the amount of the MDM2 protein compared to the condition in which the activity of the USP7 protein is not in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33229192
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"Eventually, the hepatocellular carcinoma is induced, or the inhibited USP7 protein elevates the level of the MDM2 protein compared to the condition in which the activity of the USP7 protein is not int[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33229192
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"Besides, USP7 inhibitory activity reduces MDM2 expression."
36624687