IndraLab

Statements

USP7 decreases the amount of MDM2. 3 / 7
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"UbV.7.2 inhibited USP7 in cancer cells, and consequently, caused dramatic reductions of MDM2 levels and induction of apoptosis, in synergy with cisplatin, suggesting that UbVs could be used as enhancers of chemotherapeutic drugs."
30851297
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"Indeed, downregulation of USP10 did not affect Mdm2 levels in p53 deficient cells (XREF_FIG and XREF_SUPPLEMENTARY), while downregulation of HAUSP still decreased Mdm2 levels in p53 deficient cells."
20096447
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"UbV.7.2 inhibited USP7 in cancer cells, and consequently, caused dramatic reductions of MDM2 levels and induction of apoptosis, in synergy with cisplatin, suggesting that UbVs could be used as enhancers of chemotherapeutic drugs (W. Zhang, Sartori, et al., 2017)."
30851297