IndraLab

Statements

VCL inhibits KCNH2. 3 / 3
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"Residue S631 is located towards the outer mouth of the HERG channel pore, and the S631A (serine --> alanine) mutation has been reported to shift I HERG inactivation by ~ +100 mV XREF_BIBR."
17560554
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"The hERG channels were inactivated by a holding potential of 60 mV."
16769794
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"A fast application of norquetiapine inhibited the hERG current elicited by a 5s depolarizing pulse to +60 mV, which fully inactivated the hERG currents, suggesting an inactivated-state block."
29133173