Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TP53 binds phosphorylated MDM2. 4 / 4

| 4

➶

reach

"Phosphorylated MDM2 binds to p53, expediting its degradation and interfering with tumor suppression effects of the later."

19778848

➶

reach

"It has been demonstrated that phosphorylated MDM2 binds p53 more efficiently than unphosphorylated MDM2."

20131294

➶

reach

"Similarly, Akt can phosphorylate MDM2, which enhances its nuclear localization; subsequently, the phosphorylated MDM2 binds to p53 and causes degradation of p53 by ubiquitin-proteasome pathway."

22936352

➶

reach

"After DNA damage, phosphorylated MDM2 monomers may still bind p53 and recruit activated E2, and thus can promote mono ubiquitination of p53."

20081365

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

Other Services

This Service

This Project

IndraLab

Statements

TP53 binds phosphorylated MDM2. 4 / 4

Our Sources:

Databases

Reading