IndraLab

Statements

SCN8A binds polB. 3 / 3
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"Although the mechanism is not fully understood, MED complex tightly binds to Pol II, changes its conformation and affects the transcription initiation process [XREF_BIBR, XREF_BIBR]."
26110885
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"In yeast, the 25 MED subunits are distributed within three core subcomplexes and a separable kinase module composed of Med12, Med13 and the Cdk8-CycC pair thought to control the reversible interaction between MED and PolII by phosphorylating repeated heptapeptides within the Rpb1 carboxyl-terminal domain (CTD)."
18515835
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"The phosphorylation status of Rpb1 CTD heptads is thought to play a critical role in orchestrating the reversible interaction between PolII and MED and this process may be fine tuned by the Cdk8 kinase module."
18515835