IndraLab

Statements

MTOR phosphorylates RPS6KB1. 10 / 508
| 1 301 160 33 1
reach
"Some studies suggest that mTOR can directly phosphorylate its effectors, such as S6K1 and 4E-BP1, while others claim that the mTOR dependent phosphorylation of S6K1 and 4E-BP1 is an indirect result of the inhibition of PP2A [XREF_BIBR; XREF_BIBR]."
18543252
reach
"Phosphorylation of S6K1 by mTOR in the heart is mediated by the mTOR complex 1 (mTORC1), which is sensitive to rapamycin."
22465089
reach
"42 However, inhibition of mTOR by some chemicals, such as rapa, will promote AKT phosphorylation by blocking the phosphorylation of insulin receptor substrate 1 and p70 ribosoma S6 kinase, XREF_BIBR, XREF_BIBR which are known to be a part of a negative feedback mechanism of PI3K-AKT signal transduction."
27253415
reach
"In mTORC1, mTOR binds to Raptor, mLST8 and PRAS40, and phosphorylates the translational factors S6K-1 and 4E-BP1 [XREF_BIBR], regulating different cell processes in response to nutrients and/or growth factors [XREF_BIBR]."
25840913
reach
"As previously reported in cancer cells (Mamane et al., 2006), Mtor could induce phosphorylation of p70S6K, Eif4ebp1 and cause their dissociation from Eif3 and Eif4e respectively, inducing the translat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29883638
reach
"When mTOR phosphorylates p70S6K, this kinase phosphorylates S6 ribosomal protein in return [XREF_BIBR, XREF_BIBR]."
23056046
sparser
"Further downstream, mTOR phosphorylates p70 S6 kinase (T389), a regulator of Ribosomal Protein S6 (RPS6) responsible for mRNA translation, and has been proposed to signal via 14-3-3 (tyrosine 3-monooxygenase), a required protein in Raf signaling, to inhibit IRS-1 in a negative feedback loop xref ."
21980324
reach
"An inhibitor of the mammalian target of rapamycin (mTOR) blocked the stretch induced phosphorylation of p70S6K but did not affect the eEF2 activation."
20957453
rlimsp
"To activate the translational cascade, mTOR phosphorylates S6 kinase (S6K1), which is liberated from the eIF3-complex and mobilized for activation of its downstream targets."
26172298
sparser
"Interestingly, the study has also found that autophagy activators decrease the cytotoxicity of fenofibrate, while autophagy inhibitors increase the fenofibrate-induced glioblastoma cytotoxicity including phosphorylation of AMPK and suppression of mTOR- dependent phosphorylation of p70S6K ( xref )."
33833983