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IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

MAPK1 phosphorylates RPS6KA1. 9 / 15
5 1 | 2 2 4
biopax:panther
No evidence text available
reach
"Immunolabeling of ERK1 and ERK2 and total and ERK1/2 Mediated Phosphorylation of RSK1 and MSK1."
sparser
"The D319N D-domain mutation attenuated Rsk phosphorylation by ERK2 in KN6 γδTCR + progenitors cultured on ligand-expressing OP9 monolayers ( xref ); however, it did not disrupt the interaction of ERK2 with Egr1, as measured by co-immunoprecipitation ( xref )."
rlimsp
"Notably, extracellular signal regulated kinase 2 (ERK2) phosphorylates ribosomal S6 kinase 1 (RSK1), which promotes cellular growth."
biopax:panther
No evidence text available
biopax:panther
No evidence text available
biopax:panther
No evidence text available
reach
"Of these, ERK2 (encoded by the gene MAPK1) was reported to increase the activity and phosphorylation of the oncoprotein RPS6KA1 (ribosomal protein S6 kinase, 90kDa, polypeptide A1), leading to cancer cell proliferation."
rlimsp
"PKA activity is also regulated by the interaction of other proteins with the regulatory (R) or catalytic (C) subunits of PKA, and a mechanism has been uncovered in which ribosomal S6 kinase (RSK1) interacts with either PKA subunit, depending on whether RSK1 has been phosphorylated and activated by extracellular signal-regulated kinase (ERK)."
MAPK1 phosphorylates RPS6KA1 on S363. 7 / 7
1 6 |
hprd
No evidence text available
hprd
No evidence text available
hprd
No evidence text available
signor
"Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733."
hprd
No evidence text available
hprd
No evidence text available
hprd
No evidence text available
MAPK1 phosphorylates RPS6KA1 on T359. 7 / 7
1 6 |
hprd
No evidence text available
hprd
No evidence text available
hprd
No evidence text available
signor
"Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733."
hprd
No evidence text available
hprd
No evidence text available
hprd
No evidence text available
MAPK1 phosphorylates RPS6KA1 on T573. 3 / 3
1 2 |
signor
"Thus, MAPK1/ERK1 and MAPK2/ERK2 activate three closely related protein kinases known as MAPK_activated protein kinases_1a, _1b and _1c (MAPKAP_K1a/b/c; also known as RSK1/2/3)"
signor
"Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733."
biopax:phosphositeplus
No evidence text available
MAPK1 phosphorylates RPS6KA1 on S221. 1 / 1
1 |
signor
"Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733."
MAPK1 phosphorylates RPS6KA1 on S732. 1 / 1
1 |
signor
"Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733."
MAPK1 phosphorylates RPS6KA1 on S380. 1 / 1
1 |
signor
"Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosphorylated in transfected cos-1 cells. The inactive form of mapkap-k1a in unstimulated cells is partially phosphorylated at ser222 and ser733. Stimulation with phorbol 12-myristate 13-acetate induces the phosphorylation of thr360, ser364, thr574, and ser381 and increases the phosphorylation of ser222 and ser733."