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DUSP6 dephosphorylates MAPK1. 10 / 27
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"Furthermore, MKP3 is capable of efficiently dephosphorylating both the pTyr and the pThr on ERK2."
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"Expression of LINC01503 in ESCC cell lines reduced ERK2 dephosphorylation by DUSP6, leading to activation of ERK signaling via MAPK."
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"Thus, the molecular basis for efficient dual dephosphorylation of ERK2 and pTpY by MKP3 may lie in the specific interactions between ERK2 and MKP3 that are not possible between nonspecific substrates [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"On the contrary, the knockdown of DUSP6 by si-RNA significantly enhanced the phosphorylation of ERK2 ( Figure 5D )."
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"On the other hand, when active MAPK1 was dephosphorylated by the exogenous expression of DUSP6, promoter activity was reduced."
18848526
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"We note that MKP-3 preferentially dephosphorylates ERK2, and in addition to the resolved structures of the catalytic domain and BD, a structure of ERK2 complexed with the kinase interaction motif from MKP-3 BD has been determined [ xref ]."
18855677
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"Our results also suggest that MKP3 can dephosphorylate ERK2 in cells in the absence of its N-terminal MAPK-binding domain."
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"The same study demonstrated that recombinant ERK2 can induce catalytic activation of DUSP6, and DUSP6 expression can de-phosphorylate a co-expressed ERK2 construct and block the MEK1 driven activation of GAL4-ELK1, an ERK1/2 regulated transcription factor."
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"ERK2 dephosphorylation by MKP3 has been shown to proceed by a mechanism whereby MKP3 binds to ERK2/pTpY and dephosphorylates ERK2/pY first, then dissociates and releases the monophosphorylated ERK2/pT[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"ERK2 dephosphorylation by MKP3 has been shown to proceed by a mechanism whereby MKP3 binds to ERK2 and pTpY and dephosphorylates ERK2/pY first, then dissociates and releases the monophosphorylated ERK[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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