"Sequential treatment of Taxol or cisplatin, followed by MK-2206, induced a synergistic inhibition of cell proliferation and effectively promoted cell death, either by inhibiting the phosphorylation of Akt and its downstream effectors 4E-BP1 and p70S6K in SKOV3 cells or by restoring p53 levels, which were downregulated after Taxol or cisplatin treatment, in ES2 cells."
"We further examined cisplatin induced expression levels of p53, p73, p21 waf1 and cip1, NOXA and Bax in several human ovarian cancer cell lines with different p53 status including A2780s (p53 WT), SKOV3 (p53-/-), OVCAR-3 (harboring mutant p53 R248Q) and A2780cp (containing p53 wild-type gene sequence but showing loss of p53 function)."
"Curcumin and cisplatin treatment markedly increases expression of p53 and p21 in 253J-Bv cells and decreases p-STAT3 protein levels in T24 cells."
"In this study, CDDP treatment did increase the protein levels of P53 and Bax, as well as decrease the Bcl2 expression."
"In vitro and xenograft NSCLC models have shown that sequential therapy of cisplatin and p53 gene therapy enhances p53 expression."
"According to Li Y 's results, DNA damage chemotherapeutic drugs, Doxo and CDDP, induce p53 expression and a concomitant up-regulation of WWP1 mRNA level in cells carrying wild-type p53; absence of wild-type p53 abrogates DNA damage induced increase in WWP1 mRNA and protein [XREF_BIBR]."
"These results suggest that cisplatin induced p53 protein phosphorylation and may activate the downstream of p53 gene expression such as p21 and Bax."
"Equitoxic cisplatin treatment induced a similar increase of p53 protein expression in A549 and A549 r CDDP 2000 cells (XREF_SUPPLEMENTARY)."
"Surprisingly, we noticed a markedly greater expression of p53 in response to cisplatin in A549cisR cells, although Bak and Bax induction was lower, raising the question as to how important p53 activation is, to sufficiently induce lung cancer cell death."
"Furthermore, transient knockdown of Wrap53 by siRNAs in U-2OS cells treated with 10 muM cisplatin reduced p53 mRNA transcript levels by up to 50% of those of controls."