IndraLab
Statements
reach
"Sequential treatment of Taxol or cisplatin, followed by MK-2206, induced a synergistic inhibition of cell proliferation and effectively promoted cell death, either by inhibiting the phosphorylation of Akt and its downstream effectors 4E-BP1 and p70S6K in SKOV3 cells or by restoring p53 levels, which were downregulated after Taxol or cisplatin treatment, in ES2 cells."
reach
"We further examined cisplatin induced expression levels of p53, p73, p21 waf1 and cip1, NOXA and Bax in several human ovarian cancer cell lines with different p53 status including A2780s (p53 WT), SKOV3 (p53-/-), OVCAR-3 (harboring mutant p53 R248Q) and A2780cp (containing p53 wild-type gene sequence but showing loss of p53 function)."
reach
"According to Li Y 's results, DNA damage chemotherapeutic drugs, Doxo and CDDP, induce p53 expression and a concomitant up-regulation of WWP1 mRNA level in cells carrying wild-type p53; absence of wild-type p53 abrogates DNA damage induced increase in WWP1 mRNA and protein [XREF_BIBR]."
reach
"Cisplatin can obviously inhibit the proliferation of SLC-89, change the distribution of cell cycle, decline telomerase activity and expressions of bcl-2 and PCNA proteins, and induce expression of p53 protein, which may be the important mechanisms of cisplatin 's anticancer action."
sparser
"For example, a study provided the first evidence that CK increases the efficacy of cisplatin in lung cancer by enhancing the cisplatin‐induced p53 expression and activity (Li, Zhou, et al., xref ), which indicated that the combined CK and cisplatin had better effects than either molecule alone."
reach
"Cisplatin upregulated p53 expression in p53 positive cells (XREF_FIG) and higher nuclear localization of 64 Cu from the agonists was observed for p53 positive compared to p53 negative cell lines at 24 h (XREF_FIG), suggesting that p53 plays a role in 64 Cu trafficking into the tumor cell nuclei."
reach
"Our previously published work showed that cisplatin was able to increase the p53 level in the L1210 cell induced murine cancer model, but cis-[PtCl 2 (naza) 2] complexes, that are previously reported dichlorido-analogues of the herein presented complexes, had lower effect or even decreased its level [XREF_BIBR]."
reach
"In a separate preclinical study we have demonstrated that the anticancer effect of ALT-801 could be significantly improved by increasing the density of the p53 (aa264-272)/HLA-A * 0201 complex on the tumor cell surface using chemotherapy, such as cisplatin which may induce increased p53 levels (Wong, HC, unpublished data)."
"Treatment of A549 cells with 20 microM gemcitabine, cisplatin, or taxol or with 50 microM camptothecin caused robust PARP cleavage, which was inhibited by 1 M nicotine (Fig. 1d). Drug treatment enhanced the levels of p53 and its transcriptional target, p21, as seen by Western blots; interestingly, this induction was also inhibited by nicotine."
reach
"In addition, using Western blotting we examined the cisplatin induced changes in endogenous levels of p53 (a biomarker for cell cycle and apoptosis), cyclin D1 (a biomarker for cell cycle), LC3B (a biomarker for autophagy), PARP (poly-ADP-ribose polymerase) (a biomarker for apoptosis), FAS (fatty acid synthase) (a biomarker for fatty acid synthesis), and PCNA (proliferating cell nuclear antigen) (a biomarker for proliferation) in these cell lines (XREF_FIG C)."
"Treatment of A549 cells with 20 microM gemcitabine, cisplatin, or taxol or with 50 microM camptothecin caused robust PARP cleavage, which was inhibited by 1 M nicotine (Fig. 1d). Drug treatment enhanced the levels of p53 and its transcriptional target, p21, as seen by Western blots; interestingly, this induction was also inhibited by nicotine."
reach
"Our study showed that compared with the normal control group, the episamarcandin and cisplatin groups had significantly upregulated expression levels of PTEN, p53, and Bax, whereas they significantly downregulated expression levels Akt, Bcl-xl, mTOR, and Bcl-2.It is reported that natural compounds such as calebin A and resveratrol can induce colon cancer cell apoptosis and prevent colorectal cancer metastasis by targeting SIRT1 and inhibiting NF-κB signaling [30–32]."
reach
"These results, along with our previous observations that DNA damaging agents such as cisplatin and adriamycin that increased the levels of p53 but did not up-regulate TRAL-R2 in melanoma cells [[XREF_BIBR], & data not shown], suggest that p53 may not be functionally active in melanoma cells in regard to regulation of TRAIL-R2 expression."
reach
"We found that cisplatin treatment of HNSCC cells with mutant TP53 leads to arrest of cells in the G 2 phase of the cell cycle, leading us to hypothesize that the wee-1 kinase inhibitor MK-1775 would abrogate the cisplatin induced G 2 block and thereby sensitize isogenic HNSCC cells with mutant TP53 or lacking p53 expression to cisplatin."