IndraLab

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BRAF phosphorylates MAP2K1. 10 / 58
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"We observed that 65% of anti-BRAF autoantibodies activate phosphorylation of MEK1 by BRAF in vitro."
20955560
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"BRAF proteins, Ras regulated kinase, phosphorylate MEK1 and MEK2, which in turn phosphorylate MAPK-ERK 1/2."
16404419
rlimsp
"Phosphorylation of MEK1 by BRAF was detected by Western blotting and quantified."
20955560
sparser
"We found that not BRAF WT but BRAF V600E-dependent phosphorylation of MEK1 was increased in the presence of AA ( Figure S5 D)."
26145173
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"BRAF, also known as serine/threonine protein kinase B-Raf, can phosphorylate MAP2K1 and thereby activates the MAP kinase signal transduction pathway in living cells."
33240890
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"Activated BRAF proteins phosphorylates and activates MEK1 and 2 (MAPKKs), which in turn phosphorylate and activate ERK1 and 2 (MAPKs)."
19383316
sparser
"We confirmed that B-Raf activated by cAMP phosphorylates the sites in MEK-1 (serines 218 and 222) that have previously been shown to be required for MEK activation by Raf-1 ( Alessi et al. 1994 )."
9094716
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"When BRAF is inhibited, ERK can still be activated through CRAF, and BRAF binds to and phosphorylates MEK1 and MEK2 more efficiently than CRAF [XREF_BIBR], especially in his V600E/K mutated form."
33507915
sparser
"In the context of melanoma, oncogenic BRAF V600E constitutively phosphorylates and activates the MEK1 and MEK2 kinases, which in turn phosphorylate and activate the ERK1 and ERK2 kinases, hyperactivating the canonical Mitogen Activated Protein Kinase Pathway (MAPK) to promote uncontrolled melanocytes growth and caner initiation and progression xref ."
31317143
rlimsp
"Autoantibodies to BRAF activate the phosphorylation of MEK1 by BRAF."
20955560