A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

RAF1 activates MAPK1. 9 / 24
| 1 15 1 7
reach
"Activation of Ras and Raf-1 would then result in activation of ERK-1 and ERK-2."
trips
"In the present work we show that expression of the Raf-1 autoinhibitory domain blocks extracellular signal-regulated kinase 2 activation by the Raf-1 catalytic domain in mammalian cells."
reach
"The action of the constitutively active Raf-1 was to stimulate the ERK2 kinase, whereas the dominant negative version of Raf- 1 inhibited the ERK2 activation induced by triggering of the TCR."
reach
"In this situation, markedly diminished levels of BRAF and CRAF accompanied using shRNAs, reducing ERK1 and or ERK2 levels."
reach
"Pak2 and Pak4 further activate two Raf kinases, B-Raf and C-Raf, leading to ERK1 and ERK2 (ERK1/2) activation, which all seem to be necessary for EC lumen formation."
sparser
"12,13 Raf-1-dependent activation of ERK1 and ERK2 has been demonstrated in wounded intestinal epithelial monolayers, 37 in mec[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
reach
"On the other hand, blockade of Raf-1 kinase function by overexpression of the dominant negative mutant of Raf-1 kinase completely inhibited ET-1-induced ERK2 activation."
reach
"Both TPL2 and RAF1 activates ERK1 and ERK2 via the phosphorylation of their direct upstream activator, MAPK kinase (MKK) 1/MKK2 (also known as MAP2K1 and MAP2K2 XREF_BIBR."
reach
"RAF1 proto-oncogene serine/threonine protein kinase (RAF1) can activate ERK (official gene symbol MAPK1) and/or nuclear factor-kappa B (NF-kappaB) to regulate genes involved in inflammation."
Kinase-active RAF1 activates MAPK1. 5 / 5
5 |
bel
"inhibition of CaMKII activity by specific inhibitors inhibited Erk-1/2 phosphorylation. Whereas CaMK inhibition affected neither integrin-stimulated Akt phosphorylation nor p21Ras or Mek-1 activity, it was necessary for Raf-1 activity...Active CaMKII phosphorylated Raf-1 in vitro. "
bel
"Furthermore, constitutively active Rac2, Cdc42hs, and RhoA synergize with an activated form of Raf to increase ERK2 activity"
bel
"Modified assertion"
bel
"activation of ERK depended on EGFR, Src tyrosine kinase and calcium calmodulin in PC12 cells (31), while requiring ras/Raf-1/MEK activation in human neutrophils (58)."
bel
"Activation of Raf-1 suppresses integrin activation, potentially through the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2)."
RAF1 activates MAPK1. 1 / 1
1 |
bel
"Figure 4A - When an inducible, activated Raf allele was expressed in BJ cells, Ras-GTP levels were significantly reduced within 30 min. "