IndraLab

Statements

RAF1 activates MAPK1. 10 / 30
| 1 13 1
trips
"In the present work we show that expression of the Raf-1 autoinhibitory domain blocks extracellular signal-regulated kinase 2 activation by the Raf-1 catalytic domain in mammalian cells."
12551923
reach
"The action of the constitutively active Raf-1 was to stimulate the ERK2 kinase, whereas the dominant negative version of Raf- 1 inhibited the ERK2 activation induced by triggering of the TCR."
8006597
reach
"In this situation, markedly diminished levels of BRAF and CRAF accompanied using shRNAs, reducing ERK1 and or ERK2 levels."
22277029
reach
"The evolutionarily conserved canonical mitogen-activated protein kinase (MAPK) signaling cascade—composed of the MAP3Ks ARAF, BRAF, and CRAF/RAF1 that phosphorylate and activate the MAP2Ks MEK1 and MEK2, which in turn phosphorylate and activate the MAPKs ERK1 and ERK2—drives a diverse array of cellular processes."
36400004
reach
"e phosphorylation of MEK1 and MEK2 could be stimulated by RAF1, which in turn activates the ERK1 and ERK2 to control cell cycle, apoptosis, and cell migration [34, 35] ."
35341155
reach
"Mammalian cells contain three Raf genes encoding the serine/threonine protein kinases, i. e. A-Raf, B-Raf, and Raf-1, that function as MAPK kinase kinase to initiate the ERK2 and ERK1 signaling cascad[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12644307
reach
"Activation of Ras and Raf-1 would then result in activation of ERK-1 and ERK-2."
9584148
sparser
"12,13 Raf-1-dependent activation of ERK1 and ERK2 has been demonstrated in wounded intestinal epithelial monolayers, 37 in mec[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10550332
reach
"On the other hand, blockade of Raf-1 kinase function by overexpression of the dominant negative mutant of Raf-1 kinase completely inhibited ET-1-induced ERK2 activation."
10487327
reach
"Thus catalytically inactive Raf-1, a direct target of GTP-Ras, expressed in Jurkat cells blocked TCR mediated activation of a co-expressed ERK-2 kinase reporter, suggesting that the TCR activates the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8725953
Kinase-active RAF1 activates MAPK1. 5 / 5
5 |
bel
"inhibition of CaMKII activity by specific inhibitors inhibited Erk-1/2 phosphorylation. Whereas CaMK inhibition affected neither integrin-stimulated Akt phosphorylation nor p21Ras or Mek-1 activity, it was necessary for Raf-1 activity...Active CaMKII phosphorylated Raf-1 in vitro. "
12954639
bel
"Furthermore, constitutively active Rac2, Cdc42hs, and RhoA synergize with an activated form of Raf to increase ERK2 activity"
8668187
bel
"Modified assertion"
11018025
bel
"activation of ERK depended on EGFR, Src tyrosine kinase and calcium calmodulin in PC12 cells (31), while requiring ras/Raf-1/MEK activation in human neutrophils (58)."
19273391
bel
"Activation of Raf-1 suppresses integrin activation, potentially through the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2)."
14506247
RAF1 activates MAPK1. 1 / 1
1 |
bel
"Figure 4A - When an inducible, activated Raf allele was expressed in BJ cells, Ras-GTP levels were significantly reduced within 30 min. "
17157787