"Activation of Ras and Raf-1 would then result in activation of ERK-1 and ERK-2."
"In the present work we show that expression of the Raf-1 autoinhibitory domain blocks extracellular signal-regulated kinase 2 activation by the Raf-1 catalytic domain in mammalian cells."
"The action of the constitutively active Raf-1 was to stimulate the ERK2 kinase, whereas the dominant negative version of Raf- 1 inhibited the ERK2 activation induced by triggering of the TCR."
"In this situation, markedly diminished levels of BRAF and CRAF accompanied using shRNAs, reducing ERK1 and or ERK2 levels."
"Pak2 and Pak4 further activate two Raf kinases, B-Raf and C-Raf, leading to ERK1 and ERK2 (ERK1/2) activation, which all seem to be necessary for EC lumen formation."
Raf-1-dependent activation of ERK1 and ERK2 has been demonstrated in wounded intestinal epithelial monolayers,
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"On the other hand, blockade of Raf-1 kinase function by overexpression of the dominant negative mutant of Raf-1 kinase completely inhibited ET-1-induced ERK2 activation."
"Both TPL2 and RAF1 activates ERK1 and ERK2 via the phosphorylation of their direct upstream activator, MAPK kinase (MKK) 1/MKK2 (also known as MAP2K1 and MAP2K2 XREF_BIBR."
"RAF1 proto-oncogene serine/threonine protein kinase (RAF1) can activate ERK (official gene symbol MAPK1) and/or nuclear factor-kappa B (NF-kappaB) to regulate genes involved in inflammation."