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IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

PTEN inhibits PDPK1. 7 / 7
| 7
reach
"PI3K promotes while PTEN (phosphatase and tensin homology) inhibits the activities of downstream PDK1 (3-phosphoinositide-dependent protein kinase-1) and AKT (or PKB, protein kinase B)."
reach
"A surprising result is that PTEN deletion results in strong activation of PDK1 and PKB, but bypasses the normal PDK1 requirement for cell growth and proliferation of T cells."
reach
"On the other hand, the lipid phosphatase PTEN deactivates PDK1 by transforming PIP 3 to PIP 2."
reach
"In PTEN disrupted cells, PDK1, AKT, and PKCzeta exhibited elevated basal activities, which prevented EGF induced further activation of these molecules."
reach
"Loss of PTEN leads to increased PDK1 and AKT due to PIP3 accumulation resulting in activation of mTORC1 and its downstream effectors [XREF_BIBR]."
reach
"PTEN deletion thus induces the growth and proliferation of T cell progenitors independently of PDK1."
reach
"PTEN functions as a lipid and protein phosphatase, inhibiting the ability of PDK1 to activate AKT."
Phosphatase-active PTEN inhibits PDPK1. 1 / 1
1 |
bel
"PKB phosphorylation and activity were reduced to the same extent as they were with PTEN expression. Finally we found that SHIP-2, like PTEN, caused a potent cell cycle arrest in G(1) in glioblastoma cells, which is associated with an increase in the stability of expression of the cell cycle inhibitor p27(KIP1) In these studies PtdIns(3,4,5)P3 and PtdIns(3,4)P2 were equally effective at allowing phosphorylation by PDK-1"