A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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EGFR phosphorylates RAF1 on tyrosine. 3 / 3
| 3
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"beta-AR-initiated cAMP signaling may transactivate the epidermal growth factor receptor (EGFR) pathway, including overexpression of EGFR specific phosphorylated tyrosine kinase, Raf-1, and extracellular signal regulated kinase 1/2 (ERK1/2) and ERK1/2 phosphorylation (XREF_FIG)."
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"In lung adenocarcinoma of hamsters, the overexpression of PKA, cAMP, CREB and phosphorylated CREB in beta2-adrenergic receptor pathway and EGFR specific phosphorylated tyrosine kinase, Raf-1 and ERK1/2 and their phosphorylated forms in EGFR pathway were observed [XREF_BIBR]."
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"Our immunohistochemical analysis of NNK induced PAC in hamsters demonstrates the simultaneous over-expression of a beta2-adrenergic receptor pathway, including PKA, cAMP, CREB and phosphorylated CREB and of an EGFR pathway, including over-expression of EGFR specific phosphorylated tyrosine kinase, Raf-1 and ERK1/2 and their phosphorylated forms."
EGFR leads to the phosphorylation of RAF1. 1 / 1
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bel
"Treatment of cells with a specific E-cadherin neutralizing antibodies SHE 78-7 (5 microg/ml) or HECD-1 resulted in a dose-dependent decrease in the phosphorylation levels of MEK and Raf which was induced by E-cadherin-mediated cell adhesion in the presence of calcium. It was also proved that the activation of MEK and MAPK takes place in a EGFR-dependent manner. These results indicate that cell adhesion through E-cadherin results in the activation of Raf/MEK/MAPK pathway."
EGFR leads to the phosphorylation of RAF1 on serine. 1 / 1
| 1
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"These data suggest that the activated tyrosine kinase activity of the EGF receptor enhances serine phosphorylation of RAF-1 via an intermediary molecule (s)."