IndraLab

Statements

EGFR phosphorylates PTK2. 10 / 25
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"When combining NIR-PTT with anti-EGFR-GNs in EGFR positive MDA-MB-231 cells and tumors, we observed obstruction of the EGFR mediated intracellular signal pathway (low phosphorylated mTOR, AKT, ERK1/2 and FAK levels) involved in cell proliferation and survival, as well as strong anti-proliferative (low Ki-67 level) and apoptotic activity (high cleaved caspase-3 and TUNEL levels)."
29156817
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"In order to study phosphorylation of FAK by EGF-R and alphavbeta3 activation, we determined p-FAK expression levels as a function of alphavbeta3/VN interaction and EGF-R activation by EGF."
18577466
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"FAK can be transphosphorylated by activated EGFR, and FAK function is required for EGF stimulated chemotaxis and motility [XREF_BIBR]."
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"Eighteen hours after scrape wounding, addition of HB-EGF significantly increased relative protein levels of p-FAK (1.42 +/- 0.05 vs. 1.00 +/- 0.01, p = 0.019), whereas blocking of EGFR activity with AG1478 inhibited the expression of p-FAK (0.83 +/- 0.08 vs. 1.00 +/- 0.01, p = 0.046) and also abolished HB-EGF-induced phosphorylation of FAK (0.93 +/- 0.07 vs. 1.42 +/- 0.05, p = 0.025) (XREF_FIG)."
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"RhoA-GTP-transfected cells showed a cortical array of F-actin, rounded morphology, reduced spreading potential and a dephosphorylation of FAK that was released by integrin dependent fibronectin adhesion and a specific EGFR tyrosine kinase inhibitor."
15963982
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"Another finding of our study was the observation that CD73 enhanced invasion and metastasis of HNSCC cells, mediated by activation of EGF and EGFR signaling, and its downstream phosphorylation of FAK."
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sparser
"Importantly, we have also demonstrated that Egfl7 could promote the metastasis of HCC by enhancing cell motility through EGFR-dependent FAK (focal adhesion kinase) phosphorylation [ xref ]."
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"This study demonstrated that EGF/EGFR can phosphorylate FAK and induce EMT in colorectal cancer cells.As knowledge of miRNAs continues to grow, more than 1,000 miRNAs have been identified in human gene banks."
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"However, treatment of the cells with PF573228 and a pharmacological inhibitor of EGFR, gefitinib, abrogated RCP induced EGFR, and FAK phosphorylation, respectively."
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"Another research reported that heterodimerization of proMMP-9 with CD44 can activate EGFR, which leads to phosphorylation of its downstream effectors ERK, AKT, and FAK and favors cell migration and invasion."
30538548
EGFR phosphorylates PTK2 on Y5. 2 / 2
1 1 |
signor
"In this study, we demonstrate that growth factor receptors including hepatocyte growth factor receptor met, epidermal growth factor receptor, and platelet-derived growth factor receptor directly phosphorylate fak on tyr194 in the ferm domain collectively, this study provides the first example to explain how fak is activated by receptor tyrosine kinases."
20802513
biopax:phosphositeplus
No evidence text available
EGFR phosphorylates PTK2 on tyrosine. 2 / 2
| 2
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"The ability of EGF receptor activation to stimulate tyrosine phosphorylation of p125 FAK and paxillin in rat pancreatic acini demonstrated both similarities and differences in kinetics and stoichiomet[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9990300
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"The activated EGFR signals through phosphorylated tyrosine residues to stimulate multiple pathways, including mitogen activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/Akt, signal transducers and activators of transcription (STAT), phospholipase C, and Src and focal adhesion kinase (Src and FAK) pathways."
22723871
EGFR phosphorylates PTK2 on Y194. 2 / 2
1 1 |
biopax:phosphositeplus
No evidence text available
signor
"In this study, we demonstrate that growth factor receptors including hepatocyte growth factor receptor met, epidermal growth factor receptor, and platelet-derived growth factor receptor directly phosphorylate fak on tyr194 in the ferm domain collectively, this study provides the first example to explain how fak is activated by receptor tyrosine kinases."
20802513
EGFR phosphorylates PTK2 on Y397. 1 / 1
| 1
reach
"HER2, EGFR, and additional RTKs directly phosphorylate FAK FERM at Y397."
27638858
Kinase-active EGFR leads to the phosphorylation of PTK2 on tyrosine. 1 / 1
1 |
bel
"CCh also induced association of FAK with the EGFr and FAK phosphorylation was attenuated by an EGFr inhibitor, tyrphostin AG1478, and an inhibitor of Src family kinases, PP2. The actin cytoskeleton disruptor, cytochalasin D (20 microM), abolished FAK phosphorylation in response to CCh but did not alter CCh-induced EGFr or ERK MAPK activation. "
15389641
EGFR leads to the phosphorylation of PTK2 on Y925. 1 / 1
| 1
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"Focal adhesion kinase (FAK) is an assembly point of both signaling pathways, where integrins mediate the phosphorylation of Tyr397 of FAK and the EGFR pathway induces phosphorylation of Tyr925 of FAK in a Src dependent manner [XREF_BIBR] [XREF_BIBR]."
29420611
Kinase-active EGFR leads to the phosphorylation of PTK2 on Y576. 1 / 1
1 |
bel
"This is taken from supplemental table 2 from PMID 15951569 Cut-offs were 2.25 for increase and 0.5 for decrease LLID were found by converting from GI assession numbers in DAVID Spreadsheet is saved in the project folder for Cell Signaling Project # bduckworth"
15951569