A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

EGFR activates IRS1. 3 / 3
| 1 2
reach
"Since Pak1 signaling is also affected EGFR and Akt (a target of IRS1), we next examined the levels of EGFR and IRS-1 proteins in the cell lysates used above in this study."
sparser
"In addition, IRS-1 is activated by numerous growth factor receptors such as epidermal growth factor receptor [ xref ] and hormones, including growth hormone and estrogen [ xref ]."
reach
"A potential explanation for these results is provided by in vitro data demonstrating that IRS-1 can be targeted by the EGFR."
EGFR bound to EGF activates IRS1. 1 / 1
| 1
reach
"50 Insulin, EGF, and other hormone and growth factors activate PI3K and AKT pathway by binding to the insulin receptor or EGFR, and then activate the signaling transducer IRS1."
Kinase-active EGFR activates IRS1. 1 / 1
1 |
bel
"Modified assertion"
EGFR bound to INS activates IRS1. 1 / 1
| 1
reach
"50 Insulin, EGF, and other hormone and growth factors activate PI3K and AKT pathway by binding to the insulin receptor or EGFR, and then activate the signaling transducer IRS1."