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IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

EGF activates SRC. 7 / 9
| 7
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"To test whether EGF induced src activation might induce CIN85 phosphorylation in SYF cells, we expressed wt src kinase in these cells and assessed CIN85 phosphorylation with or without EGF addition."
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"Epidermal growth factor induced stimulation of SFK activity in OV2008 cells increased PKG-Ialpha kinase activity (indicated by Ser (239) phosphorylation of the PKG substrate vasodilator stimulated phosphoprotein), which was blocked by both SKI-1 and SU6656."
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"We show that src family kinase activity is also activated by addition of EGF to PC12 cells, which endogenously express relatively high levels of EGF receptor."
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"In this report, we demonstrate EGF dependent activation of src family tyrosine kinases in NIH3T3 cells overexpressing the human EGF receptor."
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"Taken together, those data suggest that CIN85 is Tyr phosphorylated upon EGF stimulation in a src dependent manner."
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"Upon SFK activation induced by epidermal growth factor stimulation, fluorescent resonance energy transfer (FRET) response was detected transiently at membrane ruffles in COS1 cells co-expressing CFP-Csk and Cbp-YFP and in cells expressing a single-molecule FRET indicator consisting of CskSH2 and Cbp."
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"EGF, PDGF, and bFGF activate the SFK, cSrc in murine fibroblasts [XREF_BIBR], and in skeletal muscle cells insulin stimulates SFK activation [XREF_BIBR]."
EGF activates SRC. 1 / 1
1 |
bel
"Here, we found that Par3 was tyrosine phosphorylated through phosphoproteomic profiling of pervanadate-induced phosphotyrosine proteins. We also demonstrated that the tyrosine phosphorylation event induced by multiple growth factors including epidermal growth factor (EGF) was dependent on activation of Src family kinase (SFK) members c-Src and c-Yes. The tyrosine residue 1127 (Y1127) of Par3 was identified as the major EGF-induced phosphorylation site."