IndraLab
Statements
"For example, debate has raged for years as to whether Grb2, a key adaptor protein, undergoes tyrosine phosphorylation (Li et al., 2001). Here we identified two phosphorylation sites on Grb2 with certainty: Tyr169 and Tyr209, both located within the carboxy-terminal SH3 domain (see Table S2). (Taken from Discussion section)"
"We used mass spectrometry-based proteomics to comprehensively compare proteins that were tyrosine phosphorylated in response to EGF and PDGF and their associated partners. More than 90% of these signaling proteins were used by both ligands, whereas the phosphatidylinositol 3-kinase (PI3K) pathway was exclusively activated by PDGF,"