A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

EGF leads to the phosphorylation of GRB2 on Y209. 2 / 2
2 |
bel
"We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database"
bel
"For example, debate has raged for years as to whether Grb2, a key adaptor protein, undergoes tyrosine phosphorylation (Li et al., 2001). Here we identified two phosphorylation sites on Grb2 with certainty: Tyr169 and Tyr209, both located within the carboxy-terminal SH3 domain (see Table S2). (Taken from Discussion section)"
EGF leads to the phosphorylation of GRB2. 1 / 1
| 1
reach
"EGF has been shown to activate PI3K and Akt by phosphorylating growth factor receptor bound protein 2 (Grb2)-associated binder 1 (Gab1)."
EGF leads to the phosphorylation of GRB2 on tyrosine. 1 / 1
1 |
bel
"We used mass spectrometry-based proteomics to comprehensively compare proteins that were tyrosine phosphorylated in response to EGF and PDGF and their associated partners. More than 90% of these signaling proteins were used by both ligands, whereas the phosphatidylinositol 3-kinase (PI3K) pathway was exclusively activated by PDGF,"
EGF leads to the phosphorylation of GRB2 on Y160. 1 / 1
1 |
bel
"We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database"