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EGF activates AKT1. 10 / 83
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"It is unknown whether C. elegans LIN-3 and EGF signaling activates PI3K (AAP-1, PDK-1, and AGE-1 in C. elegans) or Akt (AKT-1 and AKT-2 in C. elegans); however, Insulin and IGF Signaling (IIS) has been implicated in regulating longevity through PI3K and Akt [XREF_BIBR]."
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"Binding of TGFα or EGF to EGFR promotes the activation of selected pathways: Ras/RAF/MAPK, PI3K/Akt-1, and signal transducer and transcription-activating (STAT) pathways [42,43,44,45]."
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"Interestingly, it suppressed EGF-induced pAkt and pERK1/2 signaling pathway activation [14]."
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"EGF activates AKT1 ( xref ) and PTN11, the protein tyrosine phosphatase non-receptor type 11 also known as PTP2C ( xref )."
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"In heat-shocked cells, PKBalpha was activated to a certain level without phosphorylation on Thr-308 in the activation loop and on Thr-450 and Ser-473 in the carboxyl-terminal end region, which is critical for growth-factor-induced activation of PKBalpha."
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"In rat liver epithelial cell lines, application of EGF activates the MAP kinase pathway resulting in Cx43 hyperphosphorylation on Ser255, 279 and 282 in the C-terminus of Cx43."
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"Moreover, ablating alpha6beta4 integrin function in the T4-2s by expressing the dominant negative beta4Deltacyto, reduced both basal (XREF_FIG) and EGF stimulated (XREF_FIG D) RAC activity, and overexpression of beta4WT in the S-1 cells led to an increase in both basal (XREF_FIG) and EGF stimulated RAC activity (XREF_FIG C)."
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"Consistent with previous publication [XREF_BIBR, XREF_BIBR, XREF_BIBR], knockdown of AR suppressed EGF induced up-regulation of AKT1 and AKT2 in HepG2 cells."
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"Half-maximal activation of PKBalpha and inhibition of GSK3 by insulin occurred within 2 min with a maximal effect after 5 min and, like the stimulation of glucose uptake and glycogen synthesis, the ac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, while LY294002 inhibited Akt-1 activation by EGF, neither FTI nor RhoB-GG were effectual in blocking this activity (see Fig. 4A )."
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"Figure 4 shows the inhibitory effect of gefitinib on EGFinduced autophosphorylation of EGFR, and phophorylation of Akt and ERK1/2 in three of the NSCLC cell lines. EGF stimulated EGFR autophosphorylation and activation of Akt and ERK1/2 in PC9 (A), A549 (B), and QG56 (C) cells, and activation was blocked to different extents by gefitinib."
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"Modified assertion"
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"Western blotting with the anti-phospho-Akt1 antibody, which recognizes only phosphorylated Ser-473 residue, was performed in human esophageal cancer cell lines (TE-2, TE-5, TE-8, TE-9, TE-10, and TE-12 cells) (top panel). PDGF-treated NIH3T3 cells served as a positive control. The phospho-Akt antibody demonstrated two bands at 60 kDa. The phosphorylation of Akt was enhanced by EGF stimulation in all the esophageal cancer cell lines examined, although TE-5 cells showed high basal phosphorylation of Akt."
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