IndraLab

Statements

EGF decreases the amount of EGFR. 10 / 89
4 | 63
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"Consistent with these data, this study demonstrates that systemic administration of EGF prevents aberrant overexpression of EGF-R in the intestine of mice with pneumonia."
21701422
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"The clonal line secreting high levels of sEGF displayed a 75% reduction in EGFR levels, which was not reduced further by the addition of exogenous EGF, indicating a maximal level of receptor downregulation."
9832559
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"As can be seen, PMA treatment did indeed lead to inhibition of the loss of EGFR induced by EGF."
24244711
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"EGF stimulation reduced total EGFR levels."
22830443
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"Moreover, when LOX was depleted, EGF stimulated more rapid loss of EGFR from the cell surface (XREF_FIG; XREF_SUPPLEMENTARY)."
28416796
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"However, EGF, but not AREG, further decreased the total EGFR amount (XREF_FIG, lower panel), consistent with the known ability of EGF to cause rapid EGFR down-modulation [XREF_BIBR, XREF_BIBR, XREF_BIBR] and suggesting that AREG activated EGFR might escape this negative regulation."
27709733
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"Instead of repressing cellular responses to EGF, SHIP2 causes an increase in EGF induced signaling by elevating the level of the EGF receptor (EGFR)."
24302498
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"It has been previously reported that EGF activation of EGFR leads to EGFR endocytosis and routing for degradation rather than recycling to the cell surface [47], which explains our finding that EGF stimulation diminished the level of EGFR and HLA class I/EGFR association in BxPC-3 cells."
35303241
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"Reduction of CD82 expression by RNA interference together with depletion of glycosphingolipids with P4 significantly enhanced cell motility and increased the expression of EGFR and its phosphorylation at Tyr1173 in response to EGF."
23968914
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"Therefore, a 2-fold reduction of a surface EGFr expression by EGF induced intemalization may result in significant reduction in CT sensitivity."
8630095
EGF bound to KANK2 decreases the amount of EGFR. 1 / 1
| 1
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"In SKOV-3 cells, SIP binds to epidermal growth factor receptor (EGFR) and inhibits EGF induced expression and activation of EGFR as well as cell migration."
29597272