IndraLab

Statements

EGF phosphorylates STAT1. 10 / 24
| 10 13 1
sparser
"In light of this result and the positive correlation found between EGFR and STAT1, we hypothesized that EGF may be activating STAT1 phosphorylation, mediated by JAK2."
26676749
reach
"The mecha- nism of STAT activation by receptor tyrosine kinases such as the epidermal growth factor (EGF), ptatelet derived growth factor (PDGF), and colony stimulating factor 1 (CSF1) receptors is le[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7834740
sparser
"EGF-induced phosphorylation of STAT1 was again completely blocked by our nuclear-localized EGFR inhibitor, a condition that has no effect on ERK1/2 phosphorylation (Fig.  xref )."
30250119
reach
"On the other hand, the ubiquitin RNAi did not inhibit the phosphorylation of STAT1 and ERK by IFN-gamma and EGF, respectively, suggesting that the silencing of ubiquitin expression under these experimental conditions did not have a general adverse effect on cell signaling (XREF_SUPPLEMENTARY)."
19854138
reach
"In light of this result and the positive correlation found between EGFR and STAT1, we hypothesized that EGF may be activating STAT1 phosphorylation, mediated by JAK2."
26676749
sparser
"It has been shown that EGF induces STAT-1 phosphorylation, a known downstream target of this receptor ( xref )."
19166869
sparser
"In contrast, pretreatment with trametinib drastically alters the STAT1:ERK1/2 activation ratio by completely preventing downstream phosphorylation of ERK1/2, while leading to a slight increase in EGF-induced phosphorylation of STAT1 (Fig.  xref )."
30250119
sparser
"Additionally, inhibition of endosomal signaling using an EGFR inhibitor linked to a nuclear localization signal specifically prevents EGF-induced STAT1 phosphorylation and cell death, without affecting EGFR:ERK1/2 signaling."
30250119
sparser
"On the other hand, the ubiquitin RNAi did not inhibit the phosphorylation of STAT1 and ERK by IFN-γ and EGF, respectively, suggesting that the silencing of ubiquitin expression under these experimental conditions did not have a general adverse effect on cell signaling ( xref )."
19854138
sparser
"Indeed, EGF induced STAT1 (tyrosine701) phosphorylation reaching its maximum peak at 24 hours, while total STAT1 levels remained stable ( xref )."
26676749
EGF leads to the phosphorylation of STAT1 on S727. 7 / 7
| 3 4
sparser
"It was observed that inhibition of ERK½ by U0126 in HTR-8/SVneo cells resulted in concomitant inhibition of EGF-induced increase in STAT1 and STAT3 phosphorylation at ser 727 along with inhibition of degradation of total STAT1 (Figs xref and xref )."
28542650
sparser
"Both EGF and IFN-γ are able to cause phosphorylation of Stat1 at both Tyr701 and Ser727 for its full activation."
22162832
reach
"Indeed, we found that both EGF and IFN-gamma strongly activated Stat1 phosphorylation at both Ser727 and Tyr701 in U87-EGFR cells."
22162832
sparser
"Indeed, we found that both EGF and IFN-γ strongly activated Stat1 phosphorylation at both Ser727 and Tyr701 in U87-EGFR cells."
22162832
sparser
"The effects of different cytokines on STAT1 S727 phosphorylation in WT and dKO 293 cells are shown in xref D. While the tested cytokines had little effect in the WT cells, the lower basal STAT1 S727 phosphorylation in the dKO cells (lacking CDK8/19) was increased by EGF, TNFα and serum. xref E shows that CDK8/19-independent STAT1 S727 phosphorylation in dKO 293 cells was also increased by cytotoxic drugs etoposide and Taxol; the time course of the induction of CDK8/19-independent STAT1 S727 phosphorylation by 50 nM Taxol in dKO 293 cells is shown in xref F."
31717492
reach
"While the tested cytokines had little effect in the WT cells, the lower basal STAT1 S727 phosphorylation in the dKO cells (lacking CDK8/19) was increased by EGF, TNFα and serum."
31717492
reach
"Both EGF and IFN-gamma are able to cause phosphorylation of Stat1 at both Tyr701 and Ser727 for its full activation."
22162832
EGF leads to the phosphorylation of STAT1 on Y701. 4 / 4
1 | 1 2
reach
"Indeed, we found that both EGF and IFN-gamma strongly activated Stat1 phosphorylation at both Ser727 and Tyr701 in U87-EGFR cells."
22162832
sparser
"Both EGF and IFN-γ are able to cause phosphorylation of Stat1 at both Tyr701 and Ser727 for its full activation."
22162832
bel
"The positive control EGF did increase pSTAT1 levels (Fig. 5, row 1). Methods: pSTAT1 (Tyr701) (Cell Signaling Technology, Danvers, MA)"
19168569
sparser
"Indeed, we found that both EGF and IFN-γ strongly activated Stat1 phosphorylation at both Ser727 and Tyr701 in U87-EGFR cells."
22162832
EGF leads to the phosphorylation of STAT1 on serine. 1 / 1
| 1
reach
"Moreover, we observed that inhibition of p38 MAP kinase markedly decreased phosphorylation of tyrosine 701 in STAT1, while neither EGF induced accumulation nor serine phosphorylation of STAT1 was decreased."
23178573
EGF leads to the phosphorylation of STAT1 on tyrosine. 1 / 1
| 1
reach
"First, EGF promoted the tyrosine phosphorylation of STAT1 in IEC-6 cells and caused its translocation to the nucleus."
9950769