The INDRA Database: Results

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading
AKT1S1 activates MTOR. 10 / 25
| 1 24
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"Upon phosphorylation, PRAS40 dissociates from the mTOR complex and increases mTOR kinase activity."
19276681
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"XREF_BIBR, XREF_BIBR Nevertheless, considerable evidence exists to show that insulin can enhance the activation of mTOR via stimulation of 4EBP1 binding to dimeric mTOR complex 1, XREF_BIBR and mediated by the Akt and PKB substrate PRAS40 (proline rich Akt and PKB substrate 40 kDa)."
25914534
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"The induced phosphorylation of PRAS40 has been posited to increase mTOR activity [XREF_BIBR; XREF_BIBR]."
20127721
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"Akt mediated phosphorylation of PRAS40 induces mTOR activation XREF_BIBR."
27313493
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"Several substrates overlap with AKT and mTOR signaling, including PRAS40 [XREF_BIBR], TSC2 [XREF_BIBR], 4EBP1 [XREF_BIBR], and EIF4B [XREF_BIBR - XREF_BIBR]."
27270648
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"In summary, our study identifies that phosphorylation of PRAS40 may lead to the activation of mTOR signaling pathway in CNI induced rapid progression of human renal cancer."
21886838
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"Furthermore, PRAS40 phosphorylation by Akt and association with 14-3-3, a cytosolic anchor protein, are crucial for insulin to stimulate mTOR."
17277771
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"Both kinases phosphorylate proline rich-AKT substrate 40 (PRAS40), which increases mTOR kinase activity on dissociation from mTORC1."
29401696
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"Silencing of PRAS40 by small interfering RNA suppresses the mTOR pathway signaling in response to insulin treatment in HEK293 cells, adipocytes, liver cancer cells and ESFT cells [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
28978182
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"In fact, the observed decreases in eIF4E and several other proteins necessary for mTOR signaling such as Raptor, PRAS40, cyclin D1, and stearoyl CoA desaturase (SCD) a key enzyme in fatty acid synthesis, suggest reduction in mTOR associated cell proliferation and growth [XREF_BIBR, XREF_BIBR]."
26276744
Phosphorylated AKT1S1 activates MTOR. 1 / 1
| 1
reach
"As a result, phosphorylated PRAS40 binds to the docking protein 14-3-3 to inhibit PRAS40 and activate mTOR signaling."
22873724
AKT1S1 phosphorylated on T246 activates MTOR. 1 / 1
1 |
bel
"Furthermore, PRAS40 phosphorylation by Akt and association with 14-3-3, a cytosolic anchor protein, are crucial for insulin to stimulate mTOR. -- (From Results Section) Because insulin stimulates Akt-mediated phosphorylation of PRAS40 at Thr 246 (ref. 26), we considered the possibility that PRAS40 phosphorylation may influence insulin activation of mTOR. Both wild-type PRAS40 and mutant PRAS40T246A expressed in 293T cells inhibited S6K1 phosphorylation and this inhibition was reduced on Akt1 coexpression with wild-type PRAS40 but not PRAS40T246A--"
17277771
AKT1S1 bound to p14_3_3 activates MTOR. 1 / 1
| 1
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"Under normal growth conditions, 14-3-3 protein binding to TSC2 and PRAS40 leads to mTOR activation."
24710529