A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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AKT1S1 activates MTOR. 10 / 25
| 1 24
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"Upon phosphorylation, PRAS40 dissociates from the mTOR complex and increases mTOR kinase activity."
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"XREF_BIBR, XREF_BIBR Nevertheless, considerable evidence exists to show that insulin can enhance the activation of mTOR via stimulation of 4EBP1 binding to dimeric mTOR complex 1, XREF_BIBR and mediated by the Akt and PKB substrate PRAS40 (proline rich Akt and PKB substrate 40 kDa)."
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"The induced phosphorylation of PRAS40 has been posited to increase mTOR activity [XREF_BIBR; XREF_BIBR]."
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"Akt mediated phosphorylation of PRAS40 induces mTOR activation XREF_BIBR."
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"Several substrates overlap with AKT and mTOR signaling, including PRAS40 [XREF_BIBR], TSC2 [XREF_BIBR], 4EBP1 [XREF_BIBR], and EIF4B [XREF_BIBR - XREF_BIBR]."
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"In summary, our study identifies that phosphorylation of PRAS40 may lead to the activation of mTOR signaling pathway in CNI induced rapid progression of human renal cancer."
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"Furthermore, PRAS40 phosphorylation by Akt and association with 14-3-3, a cytosolic anchor protein, are crucial for insulin to stimulate mTOR."
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"Both kinases phosphorylate proline rich-AKT substrate 40 (PRAS40), which increases mTOR kinase activity on dissociation from mTORC1."
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"Silencing of PRAS40 by small interfering RNA suppresses the mTOR pathway signaling in response to insulin treatment in HEK293 cells, adipocytes, liver cancer cells and ESFT cells [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"In fact, the observed decreases in eIF4E and several other proteins necessary for mTOR signaling such as Raptor, PRAS40, cyclin D1, and stearoyl CoA desaturase (SCD) a key enzyme in fatty acid synthesis, suggest reduction in mTOR associated cell proliferation and growth [XREF_BIBR, XREF_BIBR]."
Phosphorylated AKT1S1 activates MTOR. 1 / 1
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"As a result, phosphorylated PRAS40 binds to the docking protein 14-3-3 to inhibit PRAS40 and activate mTOR signaling."
AKT1S1 phosphorylated on T246 activates MTOR. 1 / 1
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"Furthermore, PRAS40 phosphorylation by Akt and association with 14-3-3, a cytosolic anchor protein, are crucial for insulin to stimulate mTOR. -- (From Results Section) Because insulin stimulates Akt-mediated phosphorylation of PRAS40 at Thr 246 (ref. 26), we considered the possibility that PRAS40 phosphorylation may influence insulin activation of mTOR. Both wild-type PRAS40 and mutant PRAS40T246A expressed in 293T cells inhibited S6K1 phosphorylation and this inhibition was reduced on Akt1 coexpression with wild-type PRAS40 but not PRAS40T246A--"
AKT1S1 bound to p14_3_3 activates MTOR. 1 / 1
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"Under normal growth conditions, 14-3-3 protein binding to TSC2 and PRAS40 leads to mTOR activation."