IndraLab

Statements

WT1 inhibits WT1. 8 / 16
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"Furthermore, constitute expression of the transfected WT1 gene in cancer cells inhibited the antisense effect of WT1 antisense oligomer on cell growth."
10189890
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"Phosphorylation of WT1 blocks the ability of WT1 to bind to DNA."
24927120
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"This background WT1 expression produced by non leukaemia cells was highly variable, both between and within patients, and limited the de facto sensitivity of the WT1 expression analysis."
21707751
trips
"The expressions of ERalpha and its downstream target genes were significantly repressed following overexpression of WT1, whereas the down-regulation of WT1 by WT1 shRNA could enhance ERalpha expression and the sensitivity to tamoxifen treatment in ERalpha-negative MDA468 and HCC1954 cells that express high levels of WT1."
18708366
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"Phosphorylation of WT1 causes redistribution of the protein to the cytoplasm and blocks the ability of WT1 to bind DNA."
18644985
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"However, the presence of additional, often strong expression of WT-1 in normal tissues of the female genital tract limits the utility of WT-1 in this setting."
19543245
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"Expression of WT1 +/+ in the presence of 1-octyl-D-2-hydroxyglutarate (octyl-2HG, a cell permeable form of 2HG), which inhibits the activity of all alpha-ketoglutarate-dependent TET enzymes, inhibited the ability of WT1 to alter 5-hmC levels consistent with a TET family dependent effect of WT1 (XREF_FIG)."
25482556
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"WAGR syndrome is caused by a deletion of the WT1 gene."
27798415
Mutated WT1 inhibits WT1. 1 / 1
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"Unexpectedly, overexpression of these missense WT1 mutants did not reduce wild-type WT1 activity as predicted for a dominant negative protein."
9590178
WT1 bound to WTIP inhibits WT1. 1 / 1
1 |
bel
"The partial WTIP clone, which interacted with WTIP in the two-hybrid assay, co-localized with WT1 in nuclei, co-precipitated with WT1, and inhibited WT1-dependent transcriptional activation of the amphiregulin promoter."
14736876
WT1 bound to SWI_SNF inhibits WT1. 1 / 1
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"Tbeta4 knockout mice, followed by MI, revealed a modest increase in SWI/SNF binding Wt1 ECRs and associated increase in Wt1 expression during heart injury (XREF_FIG; also in development, XREF_SUPPLEMENTARY), however, priming with exogenous Tbeta4 in Tbeta4 knockout mice, followed by MI, resulted in significantly enhanced binding of the SWI and SNF complex to Wt1 ECRs augmenting Wt1 reactivation (XREF_FIG)."
28737171