IndraLab

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TP53 leads to the phosphorylation of STAT3. 10 / 12
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"We found that, compared to the empty vector (EV), p53 silencing (sip53) rescued STAT3 phosphorylation in apigenin treated BC3 cells, confirming the role of p53 in STAT3 inhibition."
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"We found that the inhibition of STAT3 phosphorylation by AG490 down-regulated mutp53 in both cell lines ( xref ) and that also STAT3 silencing by specific siRNA reduced mutp53 expression level in U373 and Panc1 cells ( xref )."
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"Moreover, in prostate cancer cells, inactivation of both ELL-associated factor 2 (EAF2) and p53 can enhance STAT3 phosphorylation and drive tumorigenesis, and this regulation of STAT3 phosphorylation by EAF2 and/or p53 may involve multiple mechanisms [ xref ]."
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"Although the correlation of p-STAT3 staining in clinical prostate cancer specimens with EAF2 downregulation and/or nuclear p53 staining was not strong, it is consistent with our hypothesis that defects in EAF2 and/or p53 signaling can enhance STAT3 phosphorylation and promote prostate carcinogenesis."
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"In this study, the data showed that p53 bound to STAT3 and highly expressed circ-DNMT1 or p53 promoted the phosphorylation of JAK2 and STAT3."
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"These observations suggested that p53 or a p53 downstream gene product may directly or indirectly inhibit STAT3 phosphorylation or upstream activators of STAT3 such as JAK2."
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"Similar to previous studies, we observed that wild-type p53 inhibited phosphorylation of STAT-3 in response to OSM, and mutant p53 promoted the phosphorylation of STAT-3."
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"One explanation for this discrepancy proposes that additional mutations in p53 in human cancer cell lines mediate constitutive phosphorylation of Stat3, as seen in other tumor cells (Lin et al., 2002)[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Finally, 11 dose-independently induced apoptosis and autophagy, activated p53, reduced ROS production, and reduced STAT3 phosphorylation in KSHV PEL cells [78]."
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"EAF2 knockdown in prostate cancer cells and knockout in normal mouse prostate induced STAT3 (Tyr705) phosphorylation, suggesting that EAF2 is a repressor of STAT3 signaling and that p53 is insufficient to fully repress the phosphorylation of STAT3 in the absence of EAF2."
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Mutated TP53 leads to the phosphorylation of STAT3. 3 / 3
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"Similar to previous studies, we observed that wild-type p53 inhibited phosphorylation of STAT-3 in response to OSM, and mutant p53 promoted the phosphorylation of STAT-3."
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"Upon expression of various p53 hotspot missense mutants in TP53 -/- H1299 and HCT116 cells, some p53 mutants augmented Stat3 phosphorylation."
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"Further, mutant p53 has been reported to activate STAT-3 phosphorylation in human colorectal cancer cells, resulting in EMT and cell migration [XREF_BIBR]."
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Transcriptionally active TP53 leads to the phosphorylation of STAT3. 1 / 1
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"Our results demonstrate that expression of wt p53 but not mutant p53 significantly reduced tyrosine phosphorylation of Stat3 and inhibited Stat3 DNA binding activity in both DU145 and Tsu prostate cancer cell lines that express constitutively active Stat3."
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TP53 leads to the phosphorylation of STAT3 on Y705. 1 / 1
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"STAT3 phosphorylation by p53 knockdown in C4-2 cells is consistent with a previous finding that p53 transfection inhibited STAT3 phosphorylation at Tyr705 in prostate cancer cells XREF_BIBR."
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Modified mutated TP53 leads to the phosphorylation of STAT3 on tyrosine. 1 / 1
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"Our results demonstrate that expression of wt p53 but not mutant p53 significantly reduced tyrosine phosphorylation of Stat3 and inhibited Stat3 DNA binding activity in both DU145 and Tsu prostate cancer cell lines that express constitutively active Stat3."
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