IndraLab

Statements

TGFBR1 activates SERPINE1. 3 / 3
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"TGF-beta caused ALK5 mediated upregulation of PAI-1, Smad7, and fibronectin and in pericytes at lower TGF-beta concentrations than in endothelial cells."
19959647
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"Moreover, transient transfection with Nrf2 decreased PAI-1 promoter activities stimulated by either TGF-beta treatment or ALK5 cotransfection in a dose dependent manner (XREF_FIG)."
23056222
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"Indeed, lobeglitazone treatment successfully inhibited TGF-beta and ALK5 and Smad3, 4 stimulated PAI-1 promoter activity both in NRK-49F cells and RMCs (XREF_FIG)."
28256116
Kinase-active TGFBR1 activates SERPINE1. 1 / 1
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"TGF-B normally stimulates the production of the extracellular matrix by directly increasing the production of extracellular matrix proteins, including collagen and fibronectin; decreasing the production of enzymes that degrade the extracellular matrix, including collagenase,heparinase, and stromelysin; and increasing the production of proteins that inhibit enzymes that degrade the extracellular matrix, including plasminogen activator inhibitor-1 and tissue inhibitor of metalloprotease."
15774796