A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.



phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

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"Indeed, lobeglitazone treatment successfully inhibited TGF-beta and ALK5 and Smad3, 4 stimulated PAI-1 promoter activity both in NRK-49F cells and RMCs (XREF_FIG)."
"TGF-beta caused ALK5 mediated upregulation of PAI-1, Smad7, and fibronectin and in pericytes at lower TGF-beta concentrations than in endothelial cells."
"Moreover, transient transfection with Nrf2 decreased PAI-1 promoter activities stimulated by either TGF-beta treatment or ALK5 cotransfection in a dose dependent manner (XREF_FIG)."
Kinase-active TGFBR1 activates SERPINE1. 1 / 1
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"TGF-B normally stimulates the production of the extracellular matrix by directly increasing the production of extracellular matrix proteins, including collagen and fibronectin; decreasing the production of enzymes that degrade the extracellular matrix, including collagenase,heparinase, and stromelysin; and increasing the production of proteins that inhibit enzymes that degrade the extracellular matrix, including plasminogen activator inhibitor-1 and tissue inhibitor of metalloprotease."