IndraLab

Statements

TGFB1 leads to the phosphorylation of SMAD2. 10 / 626
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"Neither R(-)efonidipine (10 µM), selective T-type CCB, nor nifedipine (10 µM), selective L-type CCB, efficaciously inhibited both TGF-β1-induced Smad2 phosphorylation and [(3)H]-leucine incorporation."
21897055
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"Exposure of SHED to TGF-β1 rapidly stimulated Smad2 phosphorylation within 5-10 min of exposure, with a maximal stimulation at 30 to 60 min of incubation as analyzed by PathScan p-Smad2 enzyme-linked immunosorbent assay (ELISA) ( xref )."
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"TGF-beta1 treatment also induced phosphorylation of Smad2 and Smad3 and up-regulation of ALK5 protein, TIMP-1, and alpha2 type 1 collagen gene expression in isolated myofibroblasts."
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"In contrast, native TGF-beta1 induced only transient Smad2 phosphorylation for only one day, suggesting that pathway activation is critically dependent on TGF-beta1 presentation."
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"Concurrently, SB431542 effectively suppressed TGF-β1-induced SMAD2 phosphorylation in BV-2 microglia (Fig. xref )."
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rlimsp
"Both Smad2 and Smad3 were phosphorylated in response to TGF-beta1 beginning at 5 minutes, with maximal phosphorylation at 15 minutes, and decreasing phosphorylation by 2 hours."
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"Therefore, lower concentrations of SB were tested to identify concentrations that only inhibit TGF-β1-induced Smad2 phosphorylation ( xref )."
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"Apigenin, a natural product belonging to the flavone, decreases VEGF expression by selectively inhibiting TGF-β1-induced phosphorylation of SMAD2 and SMAD3, further supporting the functional involvement of TGF-β in angiogenesis [ xref ]."
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"Overexpression of syntenin in stable JMJD3-knockdown BZR cells significantly recovered down-regulated TGF-β1-induced Smad2 and Smad3 phosphorylation and cell migration (Fig. xref )."
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"We could clearly show that silencing of TIMP3 as well as of betaglycan strongly attenuated TGF-β2-dependent but not TGF-β1-dependent phosphorylation of Smad2 and of Smad3."
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TGFB1 phosphorylates SMAD2 on S465. 1 / 1
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"Phosphorylation of Smad2 at serine 465/467 (pSmad2) and Smad3 at serine 423/425 (pSmad3) by the activated TGFbeta1 receptor modulates their activity, allowing them to translocate to the nucleus and regulate TGFbeta1 target genes XREF_BIBR, XREF_BIBR."
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TGFB1 phosphorylates SMAD2 on cysteine. 1 / 1
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"Besides, in the TGF-β signaling pathway, TGF-β1 receptor kinases could phosphorylate Smad2 and Smad3 in the C terminal residue, resulting in forming a complex with Smad4, which plays the role of commo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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TGFB1 phosphorylates SMAD2 on S467. 1 / 1
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"Phosphorylation of Smad2 at serine 465/467 (pSmad2) and Smad3 at serine 423/425 (pSmad3) by the activated TGFbeta1 receptor modulates their activity, allowing them to translocate to the nucleus and regulate TGFbeta1 target genes XREF_BIBR, XREF_BIBR."
24075003
TGFB1 phosphorylates SMAD2 on S255. 1 / 1
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rlimsp
"TGF-β1 phosphorylated Smad2 on the non-receptor substrate sites (Ser245/250/255)."
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Modified TGFB1 leads to the phosphorylation of SMAD2. 1 / 1
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"However, the amounts of TGF-beta1 were sufficient to consistently trigger Smad2 phosphorylation in fibroblasts."
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