IndraLab

Statements

SRC inhibits RAS. 9 / 11
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"Differential antagonism of Ras biological activity by catalytic and Src homology domains of Ras GTPase activation protein."
8506332
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"Ras activation was inhibited by a Grb2 dominant negative form (P49L), by PI3K inhibitors, including wortmannin, LY294002, the N-SH2 domain of p85alpha PI3K and by the SH2 domain of Src."
11012680
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"However, as mentioned in Section 2.3.2, SRC negatively regulates RAS by phosphorylation at Y32, therefore SRC inhibition leads to increased RAS activity."
28513565
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"Moreover, we provide evidence that the inhibition of SRC may activate RAS, AKT and ERK1/2 in the cancer cells analysed."
25077442
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"Differential antagonism of Ras biological activity by catalytic and Src homology domains of Ras GTPase activation protein."
8402896
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"In stark contrast to a previous model in which Src promotes Golgi Ras activity, we showed that Src negatively regulates Ras activity at the Golgi compartment, but not at the plasma membrane (Fig. 3)."
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"The Src kinase inhibitor PP1 also reduced bFGF activation of Ras p21 and cell proliferation in PR1 cells."
15637287
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"SRC phosphorylates SHC, promoting its ability to activate RAS [XREF_BIBR]; downstream of RAS, SRC phosphorylates and activates RAF kinases [XREF_BIBR]; conversely, SRC phosphorylation also can inhibit RAS, by promoting its GTPase activity [XREF_BIBR]."
31830556
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"To explain why dasatinib and PP2 induced the phosphorylation of AKT and ERK1/2, we speculate that a negative regulatory RAS protein or upstream to RAS protein (likely a phosphatase of EGFR) might be activated by SRC kinases."
25077442
Kinase-active SRC inhibits RAS. 1 / 1
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"Src inhibition leads to activation of the Ras pathway upon PDGF stimulation."
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